Evidence map›Paper›PMID 34531936›Full record

ArticleThe annals of applied statistics2020

ANALYSES OF PREVENTIVE CARE MEASURES WITH INCOMPLETE HISTORICAL DATA IN ELECTRONIC MEDICAL RECORDS: AN EXAMPLE FROM COLORECTAL CANCER SCREENING.

Yingye Zheng, Douglas A Corley, Chyke Doubeni, Ethan Halm, Susan M Shortreed, William E Barlow, Ann Zauber, Tor Devin Tosteson, Jessica Chubak

Abstract read
In one paragraph

Article in The annals of applied statistics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yingye ZhengDepartment of Biostatistics, Fred Hutchinson Cancer Research Center, Seattle WA.
Douglas A CorleyDivision of Research, Kaiser Permanente Northern California, Oakland, CA.
Chyke DoubeniPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Ethan HalmHarold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical School, Dallas TX.
Susan M ShortreedHealth Research Institute, Kaiser Permanente Washington, Seattle WA.
William E BarlowCancer Research and Biostatistics, Seattle WA.
Ann ZauberEpidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Tor Devin TostesonBiomedical Data Science, Dartmouth College, Hanover, NH.
Jessica ChubakHealth Research Institute, Kaiser Permanente Washington, Seattle WA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Optimizing Colorectal Cancer Screening PREcision and Outcomes in CommunIty-baSEd Populations (PRECISE)UM1CA222035 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI CHUBAK, JESSICA, CORLEY, DOUGLAS ALLEN · 2018 to 2023
$15.6M
Optimizing the use of colonoscopy for CRC screening in a large community-basedU54CA163262 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI CORLEY, DOUGLAS ALLEN, DOUBENI, CHYKE ABADAMA · 2011 to 2017
$9.6M
Parkland-UT Southwestern PROSPR Center Colon Cancer Screening in a Safety netU54CA163308 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SKINNER, CELETTE SUGG · 2011 to 2017
$8.0M
Studying Colorectal Cancer Effectiveness of Screening Strategies (SuCCESS)U54CA163261 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI CHUBAK, JESSICA · 2011 to 2017
$7.3M
Coordinating Center for Population-based Research to Optimize Cancer Screening (PROSPR) (U24)U24CA221936 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LI, CHRISTOPHER I, ZHENG, YINGYE · 2018 to 2023
$5.7M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA023108NCI NIH HHS U24 CA221936NCI NIH HHS U54 CA163261NCI NIH HHS U54 CA163262NCI NIH HHS U54 CA163308NCI NIH HHS UM1 CA222035
6 · The paper itself

Abstract

The calculation of quality of care measures based on electronic medical records (EMRs) may be inaccurate because of incomplete capture of past services. We evaluate the influence of different statistical approaches for calculating the proportion of patients who are up-to-date for a preventive service, using the example of colorectal cancer (CRC) screening. We propose an extension of traditional mixture models to account for the uncertainty in compliance, which is further complicated by the choice of various screening modalities with different recommended screening intervals. We conducted simulation studies to compare various statistical approaches and demonstrated that the proposed method can alleviate bias when individuals with complete prior medical history information were not representative of the targeted population. The method is motivated by and applied to data from the National Cancer Institute-funded consortium Population-Based Research Optimizing Screening through Personalized Regiments (PROSPR). Findings from the application are important for the evaluation of appropriate use of preventive care and provide a novel tool for dealing with similar analytical challenges with EMR data in broad settings.

Indexed as

Cancer ScreeningEMR dataEvent-time analysisMixture Model

Identifiers

PMID34531936
PMCPMC8442666

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.