Evidence map›Paper›PMID 34531866›Full record

ArticleFrontiers in immunology2021

The Effect of JAK1/2 Inhibitors on HIV Reservoir Using Primary Lymphoid Cell Model of HIV Latency.

Lesley R de Armas, Christina Gavegnano, Suresh Pallikkuth, Stefano Rinaldi, Li Pan, Emilie Battivelli, Eric Verdin, Ramzi T Younis, Rajendra Pahwa, Siôn L Williams and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. The STAT Signaling Pathway in HIV-1 Infection: Roles and Dysregulation.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Sustained antiviral response againstFrontiers in pharmacology · 2024
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Lesley R de ArmasDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
Christina GavegnanoDepartment of Pathology and Experimental Medicine, Emory University and Children's Healthcare of Atlanta, Atlanta, GA, United States.
Suresh PallikkuthDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
Stefano RinaldiDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
Li PanDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
Emilie BattivelliGladstone Institute of Virology and Immunology, Gladstone Institutes, San Francisco, CA, United States.
Eric VerdinGladstone Institute of Virology and Immunology, Gladstone Institutes, San Francisco, CA, United States.
Ramzi T YounisDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United States.
Rajendra PahwaDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
Siôn L WilliamsDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States.
Raymond F SchinaziCenter for AIDS Research, Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, GA, United States.
Savita PahwaDepartment of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, United States.
University of Miami · USBuck Institute for Research on Aging · USChildren's Healthcare of Atlanta · USEmory University · USGladstone Institutes · US

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALLAN E RODRIGUEZ · 2007 to 2026
$33.8M
NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI073961
6 · The paper itself

Abstract

HIV eradication is hindered by the existence of latent HIV reservoirs in CD4

Indexed as

CD4-Positive T-LymphocytesGene Expression ProfilingHIV-1HIV InfectionsHumansImmunophenotypingJanus Kinase 1Janus Kinase 2Janus Kinase InhibitorsLymphocyte ActivationPalatine TonsilSignal TransductionSingle-Cell AnalysisSTAT Transcription FactorsTranscriptomeVirus ActivationJAK1 protein, humanJAK2 protein, humanJanus Kinase 1Janus Kinase 2Janus Kinase InhibitorsSTAT Transcription FactorsHIVJAK-STAT signaling pathwaylatencyLRA (latency reversing agent)scRNAseqtonsil

Identifiers

PMID34531866
PMCPMC8438319
OpenAlexW3196340837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.