Evidence map›Paper›PMID 34531865›Full record

ArticleFrontiers in immunology2021

Host Genetics and Antiviral Immune Responses in Adult Patients With Multisystem Inflammatory Syndrome.

Andreas Ronit, Sofie E Jørgensen, Casper Roed, Robert Eriksson, Ulrik W Iepsen, Ronni R Plovsing, Merete Storgaard, Finn Gustafsson, Ann-Brit E Hansen, Trine H Mogensen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

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  5. Severe COVID-19European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Andreas RonitDepartment of Infectious Diseases 144, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
Sofie E JørgensenDepartment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
Casper RoedDepartment of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Robert ErikssonDepartment of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Ulrik W IepsenDepartment of Anaesthesiology and Intensive Care, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
Ronni R PlovsingDepartment of Anaesthesiology and Intensive Care, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
Merete StorgaardDepartment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
Finn GustafssonDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Ann-Brit E HansenDepartment of Infectious Diseases 144, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
Trine H MogensenDepartment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
University of Copenhagen · DKAarhus University Hospital · DKHvidovre Hospital · DKAarhus University · DKNovo Nordisk Foundation · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 associated multisystem inflammatory syndrome (MIS) is a rare condition mostly affecting children but also adults (MIS-A). Although severe systemic inflammation and multiorgan dysfunction are hallmarks of the syndrome, the underlying pathogenesis is unclear. We aimed to provide novel immunological and genetic descriptions of MIS-A patients. Cytokine responses (IL-6, IL-1β, TNFα, CXCL10, type I, II and III interferons) following SARS-CoV-2 infection of peripheral blood mononuclear cells

Indexed as

AdultAutoantibodiesChemokine CXCL10ComorbidityCOVID-19CytokinesExomeExome SequencingFemaleHumansInterferon-alphaInterferon LambdaInterferonsLeukocytes, MononuclearMaleMiddle AgedAutoantibodiesChemokine CXCL10CXCL10 protein, humanCytokinesInterferon-alphaInterferon LambdaInterferonscoronavirus disease 2019interferonmultisystem inflammatory syndromeSARS-CoV-2whole exome sequencing

Identifiers

PMID34531865
PMCPMC8439578
OpenAlexW3196981681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.