Evidence map›Paper›PMID 34531743›Full record

ArticleFrontiers in pharmacology2021

Jeffrey Warner, Josiah Hardesty, Ying Song, Rui Sun, Zhongbin Deng, Raobo Xu, Xinmin Yin, Xiang Zhang, Craig McClain, Dennis Warner and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Review
  6. Article
  7. Biology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jeffrey WarnerDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY, United States.
Josiah HardestyDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY, United States.
Ying SongDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY, United States.
Rui SunJames Graham Brown Cancer Center, University of Louisville, Louisville, KY, United States.
Zhongbin DengJames Graham Brown Cancer Center, University of Louisville, Louisville, KY, United States.
Raobo XuUniversity of Louisville Alcohol Research Center, University of Louisville School of Medicine, Louisville, KY, United States.
Xinmin YinUniversity of Louisville Alcohol Research Center, University of Louisville School of Medicine, Louisville, KY, United States.
Xiang ZhangUniversity of Louisville Alcohol Research Center, University of Louisville School of Medicine, Louisville, KY, United States.
Craig McClainDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY, United States.
Dennis WarnerDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY, United States.
Irina KirpichDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY, United States.
University of Louisville · USJames Graham Brown Foundation · US

Funding

UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAMT32ES011564 · NIEHS · UNIVERSITY OF LOUISVILLE · PI David W Hein, John Pierce Wise · 2004 to 2026
$7.1M
The role of dietary unsaturated fat and inflammasome in alcoholic liver diseaseR01AA024102 · NIAAA · UNIVERSITY OF LOUISVILLE · PI KIRPICH, IRINA A. · 2016 to 2020
$1.7M
RvD1-FPR2 signaling ameliorates alcoholic liver diseaseF32AA027950 · NIAAA · UNIVERSITY OF LOUISVILLE · PI HARDESTY, JOSIAH E · 2020 to 2022
$164k
sEH Inhibition in Alcoholic Liver Disease: A Novel Therapeutic StrategyF31AA028423 · NIAAA · UNIVERSITY OF LOUISVILLE · PI WARNER, JEFFREY B · 2020 to 2022
$92k
NIAAA NIH HHS F31 AA028423NIAAA NIH HHS F32 AA027950NIAAA NIH HHS L30 AA027913NIAAA NIH HHS R01 AA024102NIEHS NIH HHS T32 ES011564
6 · The paper itself

Abstract

Alcohol-associated liver disease (ALD) is the leading cause of liver disease worldwide, and alcohol-associated hepatitis (AH), a severe form of ALD, is a major contributor to the mortality and morbidity due to ALD. Many factors modulate susceptibility to ALD development and progression, including nutritional factors such as dietary fatty acids. Recent work from our group and others showed that modulation of dietary or endogenous levels of n6-and n3-polyunsaturated fatty acids (PUFAs) can exacerbate or attenuate experimental ALD, respectively. In the current study, we interrogated the effects of endogenous n3-PUFA enrichment in a mouse model which recapitulates features of early human AH using transgenic

Indexed as

alcohol-associated liver disease (ALD)fat-1n3 polyunsaturated fatty acids (n-3PUFAs)NIAAA modelplasminogen activator inhibitor (PAI-1)

Identifiers

PMID34531743
PMCPMC8438569
OpenAlexW3198753914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.