Evidence map›Paper›PMID 34531709›Full record

ArticleAdvanced functional materials2018

Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants.

Shoumyo Majumdar, Xiaokun Wang, Sven D Sommerfeld, Jemin Jeremy Chae, Evangelia-Nefeli Athanasopoulou, Lucas S Shores, Xiaodong Duan, L Mario Amzel, Francesco Stellacci, Oliver Schein and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Biomimetic Convex Implant for Corneal Regeneration Through 3D Printing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Biomechanics of Ophthalmic Crosslinking.Translational vision science & technology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shoumyo MajumdarTranslational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231, USA.
Xiaokun WangTranslational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231, USA.
Sven D SommerfeldTranslational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231, USA.
Jemin Jeremy ChaeTranslational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231, USA.
Evangelia-Nefeli AthanasopoulouSupramolecular Nanomaterials and Interfaces Laboratory, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Lucas S ShoresDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Xiaodong DuanEyegenix LLC, Honolulu, HI 96817, USA.
L Mario AmzelDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University, Baltimore, MD 21205, USA.
Francesco StellacciSupramolecular Nanomaterials and Interfaces Laboratory, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Oliver ScheinWilmer Eye Institute, Johns Hopkins School of Medicine Baltimore, MD 21231, USA.
Qiongyu GuoDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Anirudha SinghTranslational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231, USA.
Jennifer H ElisseeffTranslational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231, USA.

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Jiang Qian · 1985 to 2026
$22.1M
Statistical optimization of self-assembled biosynthetic cornea implantsR01EY029055 · NEI · JOHNS HOPKINS UNIVERSITY · PI ELISSEEFF, JENNIFER H · 2018 to 2021
$1.8M
NEI NIH HHS P30 EY001765NEI NIH HHS R01 EY029055
6 · The paper itself

Abstract

Collagen-rich tissues in the cornea exhibit unique and highly organized extracellular matrix ultrastructures, which contribute to its high load-bearing capacity and light transmittance. Corneal collagen fibrils are controlled during development by small leucine-rich proteoglycans (SLRPs) that regulate the fibril diameter and spacing in order to achieve the unique optical transparency. Cyclodextrins (CDs) of varying size and chemical functionality for their ability to regulate collagen assembly during vitrification process are screened in order to create biosynthetic materials that mimic the native cornea structure. Addition of

Indexed as

collagencorneacyclodextrinsfibril alignmentself-assembly

Identifiers

PMID34531709
PMCPMC8442673

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.