Evidence map›Paper›PMID 34531703›Full record

ArticleMediators of inflammation2021

Human Acellular Amniotic Matrix with Previously Seeded Umbilical Cord Mesenchymal Stem Cells Restores Endometrial Function in a Rat Model of Injury.

Shan Wang, Cheng Shi, Xiaohui Cai, Yanbin Wang, Xi Chen, Hongjing Han, Huan Shen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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  17. Repairing and Regenerating Injured Endometrium Methods.Reproductive sciences (Thousand Oaks, Calif.) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shan WangPeking University People's Hospital, Reproductive Medicine Center, Beijing 100044, China.ORCID https://orcid.org/0000-0002-0273-8397
Cheng ShiPeking University People's Hospital, Reproductive Medicine Center, Beijing 100044, China.ORCID https://orcid.org/0000-0003-1412-9529
Xiaohui CaiBeijing Friendship Hospital, Capital Medical University, Department of Obstetrics and Gynecology, Beijing 100050, China.ORCID https://orcid.org/0000-0003-4696-7949
Yanbin WangPeking University People's Hospital, Reproductive Medicine Center, Beijing 100044, China.ORCID https://orcid.org/0000-0002-5622-8106
Xi ChenPeking University People's Hospital, Reproductive Medicine Center, Beijing 100044, China.ORCID https://orcid.org/0000-0002-1349-9176
Hongjing HanPeking University People's Hospital, Reproductive Medicine Center, Beijing 100044, China.ORCID https://orcid.org/0000-0001-8883-8550
Huan ShenPeking University People's Hospital, Reproductive Medicine Center, Beijing 100044, China.ORCID https://orcid.org/0000-0001-9373-0050
Peking University · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAbnormal endometrial repair after injury results in the formation of intrauterine adhesions (IUA) and a thin endometrium, which are key causes for implantation failure and infertility. Stem cell transplantation offers a potential alternative for some cases of severe Asherman's syndrome that cannot be treated with surgery or hormonal therapy. Umbilical cord-derived mesenchymal stem cells (UCMSCs) have been reported to repair the damaged endometrium. However, there is no report on the effects of UCMSCs previously seeded on human acellular amniotic matrix (AAM) on endometrial injury.

methodsAbsolute ethanol was injected into rat uteri to damage the endometrium. UCMSCs previously seeded on AAM were surgically transplanted. Using a variety of methods, the treatment response was assessed by endometrial thickness, endometrial biomarker expression, endometrial receptivity, cell proliferation, and inflammatory factors.

resultsEndometrial thickness was markedly improved after UCMSC-AAM transplantation. The expression of endometrial biomarkers, namely, vimentin, cytokeratin, and integrin

conclusionsUCMSC transplantation using AAM as the carrier can be applied to treat endometrial injury in rats. The successful preparation of lyophilized AAM provides the possibility of secondary infectious disease screening and amniotic matrix quality detection, followed by retrospective analysis. The UCMSC-AAM complex may promote the better application of UCMSCs on the treatment of injured endometrium.

Indexed as

AmnionAnimalsBiomarkersCell TransplantationDisease Models, AnimalEndometriumFemaleHumansInflammationIntegrinsKeratinsMesenchymal Stem CellsPlacentaPregnancyRatsRats, Sprague-DawleyBiomarkersIntegrinsKeratinsVimentin

Identifiers

PMID34531703
PMCPMC8438588
OpenAlexW3196415307

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.