Evidence map›Paper›PMID 34531701›Full record

ArticleEuropean journal of organic chemistry2020

Preparation and mechanistic studies of 2-substituted Bisthiazolidines by imine exchange.

Verónica Martínez, Valentina Villamil, Diego Duarte, Cecilia Saiz, Danilo Davyt, Carolina Fontana, Nicolás Veiga, Graciela Mahler

Open access · greenAbstract read
In one paragraph

Article in European journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Verónica MartínezLaboratorio de Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, Avda. General Flores 2124, CC1157, Universidad de la República (UdelaR), Montevideo, Uruguay.
Valentina VillamilLaboratorio de Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, Avda. General Flores 2124, CC1157, Universidad de la República (UdelaR), Montevideo, Uruguay.
Diego DuarteLaboratorio de Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, Avda. General Flores 2124, CC1157, Universidad de la República (UdelaR), Montevideo, Uruguay.
Cecilia SaizLaboratorio de Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, Avda. General Flores 2124, CC1157, Universidad de la República (UdelaR), Montevideo, Uruguay.
Danilo DavytLaboratorio de Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, Avda. General Flores 2124, CC1157, Universidad de la República (UdelaR), Montevideo, Uruguay.
Carolina FontanaLaboratorio de Espectroscopía y Fisicoquímica Orgánica, Departamento de Química del Litoral, CENUR Litoral Norte (S.R.A. Facultad de Química), Ruta 3 km 363, UdelaR, Paysandú, Uruguay.
Nicolás VeigaQuímica Inorgánica, Departamento Estrella Campos, Facultad de Química, General Flores 2124, CC1157, UdelaR, Montevideo, Uruguay.
Graciela MahlerLaboratorio de Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, Avda. General Flores 2124, CC1157, Universidad de la República (UdelaR), Montevideo, Uruguay.
Universidad de la República de Uruguay · UYCentro Uruguayo de Imagenología Molecular · UY

Funding

A Mechanism-Based Approach to Metallo-beta-Lactamase InhibitionR01AI100560 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., SPENCER, JAMES · 2012 to 2022
$4.4M
NIAID NIH HHS R01 AI100560
6 · The paper itself

Abstract

Bisthiazolidines (BTZ) are bicyclic compounds considered penicillin analogs that inhibit the full range of Metallo-β-Lactamases (MBLs) and potentiate β-lactam activity against resistant bacteria. Herein we present a new methodology to prepare 2-substituted bisthiazolidines by aldehyde exchange. Thirteen new bisthiazolidines were prepared using this methodology, with yields ranged from 31 to 75%. The reaction is based on

Indexed as

bisthiazolidinesimine exchangemetathesis microwave chemistry

Identifiers

PMID34531701
PMCPMC8442850
OpenAlexW2999158940

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.