Evidence map›Paper›PMID 34531520›Full record

ArticleCommunications biology2021

Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain.

Mineki Oguchi, Shingo Tanaka, Xiaochuan Pan, Takefumi Kikusui, Keiko Moriya-Ito, Shigeki Kato, Kazuto Kobayashi, Masamichi Sakagami

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2024
    Review
  5. Article
  6. Review
  7. Multimodal Imaging for Validation and Optimization of Ion Channel-Based Chemogenetics in Nonhuman Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  8. Article
  9. Article
  10. Crossed Corticostriatal Projections in the Macaque Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  11. Article
  12. Applications of chemogenetics in non-human primates.Current opinion in pharmacology · 2022
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Mineki OguchiBrain Science Institute, Tamagawa University, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4163-6868
Shingo TanakaBrain Science Institute, Tamagawa University, Tokyo, Japan.
Xiaochuan PanInstitute for Cognitive Neurodynamics, East China University of Science and Technology, Shanghai, China.
Takefumi KikusuiSchool of Veterinary Medicine, Azabu University, Kanagawa, Japan.ORCID http://orcid.org/0000-0002-3134-5859
Keiko Moriya-ItoTokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Shigeki KatoDepartment of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, Fukushima, Japan.
Kazuto KobayashiDepartment of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, Fukushima, Japan.ORCID http://orcid.org/0000-0002-7617-2939
Masamichi SakagamiBrain Science Institute, Tamagawa University, Tokyo, Japan. sakagami@lab.tamagawa.ac.jp.ORCID http://orcid.org/0000-0003-1989-2793
Tamagawa University · JPFukushima Medical University · JPAzabu University · JPEast China University of Science and Technology · CNTokyo Metropolitan Institute of Medical Science · JP

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research on Innovative Areas 4303MEXT | Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research on Innovative Areas 4805MEXT | Japan Society for the Promotion of Science (JSPS) KAKENHI JP18H03662
6 · The paper itself

Abstract

The lateral prefrontal cortex (LPFC) has a strong monosynaptic connection with the caudate nucleus (CdN) of the striatum. Previous human MRI studies have suggested that this LPFC-CdN pathway plays an important role in inhibitory control and working memory. We aimed to validate the function of this pathway at a causal level by pathway-selective manipulation of neural activity in non-human primates. To this end, we trained macaque monkeys on a delayed oculomotor response task with reward asymmetry and expressed an inhibitory type of chemogenetic receptors selectively to LPFC neurons that project to the CdN. Ligand administration reduced the inhibitory control of impulsive behavior, as well as the task-related neuronal responses observed in the local field potentials from the LPFC and CdN. These results show that we successfully suppressed pathway-selective neural activity in the macaque brain, and the resulting behavioral changes suggest that the LPFC-CdN pathway is involved in inhibitory control.

Indexed as

AnimalsClozapineCorpus StriatumEye MovementsGenetic VectorsMacaca fuscataMaleMemory, Short-TermNeuronsPrefrontal CortexReaction TimeReceptors, G-Protein-CoupledRewardSynaptic TransmissionTransduction, GeneticClozapineclozapine N-oxideReceptors, G-Protein-Coupled

Identifiers

PMID34531520
PMCPMC8446038
OpenAlexW3200248876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.