Evidence map›Paper›PMID 34531482›Full record

ArticleScientific reports2021

A potential probiotic Leuconostoc mesenteroides TBE-8 for honey bee.

Yu-Han Huang, Yu-Hsin Chen, Jui-Hung Chen, Pei-Shou Hsu, Tzu-Hsien Wu, Chuen-Fu Lin, Chi-Chung Peng, Ming-Cheng Wu

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Host-AdaptedMicroorganisms · 2026
    Article
  2. Impact of Direct-Fed Microorganism Syrup on Honey Bee (Animals : an open access journal from MDPI · 2026
    Article
  3. Review
  4. Probiotic Potential ofVeterinary sciences · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Isolation and characterization ofSaudi journal of biological sciences · 2023
    Article
  10. Article
  11. Article
  12. Review
  13. A Novel Strain of ProbioticMicroorganisms · 2023
    Article
  14. Review
  15. A Potential Fungal ProbioticJournal of fungi (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yu-Han HuangDepartment of Entomology, College of Agriculture and Natural Resources, National Chung Hsing University, Taichung, Taiwan.
Yu-Hsin ChenDepartment of Entomology, College of Agriculture and Natural Resources, National Chung Hsing University, Taichung, Taiwan.
Jui-Hung ChenDepartment of Entomology, College of Agriculture and Natural Resources, National Chung Hsing University, Taichung, Taiwan.
Pei-Shou HsuDepartment of Entomology, College of Agriculture and Natural Resources, National Chung Hsing University, Taichung, Taiwan.
Tzu-Hsien WuDepartment of Entomology, College of Agriculture and Natural Resources, National Chung Hsing University, Taichung, Taiwan.
Chuen-Fu LinDepartment of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan.
Chi-Chung PengDepartment of Biotechnology, National Formosa University, Yunlin, Taiwan.
Ming-Cheng WuDepartment of Entomology, College of Agriculture and Natural Resources, National Chung Hsing University, Taichung, Taiwan. mcwu@nchu.edu.tw.
National Chung Hsing University · TWCouncil of Agriculture · TWNational Formosa University · TWNational Pingtung University of Science and Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An isolated bacterium TBE-8, was identified as Leuconostoc mesenteroides according to the sequences of 16S rDNA and the 16S-23S rDNA intergenic spacer region. The probiotic properties of the L. mesenteroides TBE-8 strain were characterized and revealed that TBE-8 could utilize various carbohydrates, exhibited high tolerance to sucrose's osmotic pressure and acidic conditions, and could mitigate the impact of the bee pathogen Paenibacillus larvae. In addition, we found that the TBE-8 broth increased the expression of the nutrition-related genes major royal jelly protein 1 and vitellogenin in bees by approximately 1400- and 20-fold, respectively. The expression of genes encoding two antibacterial peptides, hymenoptaecin and apidaecin, in the bee abdomen was significantly increased by 17- and 7-fold in bees fed with the TBE-8 fermented broth. Furthermore, we fed four-frame bee colonies with 50% sucrose syrup containing TBE-8 and can detect the presence of approximately 2 × 10

Indexed as

Disease ResistanceProbioticsAnimalsAntimicrobial Cationic PeptidesBeesCarbohydrate MetabolismGlycoproteinsInsect ProteinsLeuconostoc mesenteroidesPaenibacillus larvaeRNA, Ribosomal, 16SVitellogeninsAntimicrobial Cationic PeptidesapidaecinGlycoproteinshymenoptaecin protein, Apis melliferaInsect ProteinsMRJP1 protein, Apis melliferaRNA, Ribosomal, 16SVitellogenins

Identifiers

PMID34531482
PMCPMC8446051
OpenAlexW3198947476

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.