ArticleScientific reports2021
Persistent hyperammonia and altered concentrations of urea cycle metabolites in a 5-day swine experiment of sepsis.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- "L-Ornithine Liposomal Nanoparticles Targeting the Proline Cycle: A Mechanistic Perspective for Ammonia-Driven Hepatic Encephalopathy".Cell biochemistry and biophysics · 2026Review
- Maternal Rumen-Protected Leucine Supplementation Enhances Placental Nutrient Transport Capacity and Increases Birth Weight in Hu Sheep.Veterinary sciences · 2026Article
- Estimation of pulse wave analysis indices from invasive arterial blood pressure only for a clinical assessment of wave reflection in a 5-day septic animal experiment.Medical & biological engineering & computing · 2025Article
- Parenclitic network mapping predicts survival in critically ill patients with sepsis.Physiological reports · 2025Article
- First Report ofPlants (Basel, Switzerland) · 2025Article
- Muscle stem cells contribute to long-term tissue repletion following surgical sepsis.Journal of cachexia, sarcopenia and muscle · 2023Article
- Autonomic and circulatory alterations persist despite adequate resuscitation in a 5-day sepsis swine experiment.Scientific reports · 2022Article
- Metabolites Concentration in Plasma and Heart Tissue in Relation to High Sensitive Cardiac Troponin T Level in Septic Shock Pigs.Metabolites · 2022Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We measured plasma and cerebrospinal fluid (CSF) metabolite concentrations in a 5-day porcine sepsis model of fecal peritonitis. The objectives were: (i) to verify whether the expected pathways that had emerged in previous studies pertain only to the early inflammatory response or persist for the subsequent days; (ii) to identify metabolic derangements that arise later; (iii) to verify whether CSF metabolite concentrations were altered and if these alterations were similar to those in the blood or delayed. We observed an early response to inflammation and cytokine storms with alterations in lipid and glucose metabolism. The arginine/asymmetric dimethylarginine (ADMA) and phenylalanine/tyrosine balances changed 24 h after resuscitation in plasma, and later in CSF. There was a rise in ammonia concentration, with altered concentrations of metabolites in the urea cycle. Whether persistent derangement of these pathways have a role not only on short-term outcomes but also on longer-term comorbidities, such as septic encephalopathy, should be addressed in further studies.
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Registered trials
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