ArticleScientific reports2021
Musical components important for the Mozart K448 effect in epilepsy.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06425029 (SONATA), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SONATA: Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application
Who cites it
12 citing papers in PubMed.
- Effects of Mozart-Orff parent-child music therapy among mothers and their preschool children with autism spectrum disorder: A mixed-methods randomised controlled trial.BMC pediatrics · 2024Trial
- Multisensory flicker modulates widespread brain networks and reduces interictal epileptiform discharges.Nature communications · 2024Trial
- Impact of maternal hypothyroidism during pregnancy on neonatal corpus callosum development: a transcranial ultrasound analysis.Frontiers in neuroscience · 2026Article
- Beyond immersion: the cognitive mechanics of functional ludomusicology in esports performance.Frontiers in psychology · 2026Review
- Intraoperative Music During General Anaesthesia in Dogs Undergoing Elective Ovariohysterectomy: A Prospective, Double-Blinded Randomized Exploratory Study.Animals : an open access journal from MDPI · 2025Article
- Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage.IBRO neuroscience reports · 2025Article
- Proposed Physiological and Neurobiological Mechanisms of Music's Effect, with a Focus on the Perioperative Period: Literature Evidence from Human, Canine and Feline Medicine.Veterinary sciences · 2025Review
- Toward a Tailored Acoustic-Based Approach in Music Neuromodulation in Epilepsy.European journal of neurology · 2025Article
- The bidirectional role of music effect in epilepsy: Friend or foe?Epilepsia open · 2024Review
- Proceedings of the 2022 "Lifestyle Intervention for Epilepsy (LIFE)" symposium hosted by Cleveland Clinic.Epilepsia open · 2024Article
- Digital Therapeutics for Improving Effectiveness of Pharmaceutical Drugs and Biological Products: Preclinical and Clinical Studies Supporting Development of Drug + Digital Combination Therapies for Chronic Diseases.Journal of clinical medicine · 2024Review
- Evoked responses to note onsets and phrase boundaries in Mozart's K448.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
There is growing evidence for the efficacy of music, specifically Mozart's Sonata for Two Pianos in D Major (K448), at reducing ictal and interictal epileptiform activity. Nonetheless, little is known about the mechanism underlying this beneficial "Mozart K448 effect" for persons with epilepsy. Here, we measured the influence that K448 had on intracranial interictal epileptiform discharges (IEDs) in sixteen subjects undergoing intracranial monitoring for refractory focal epilepsy. We found reduced IEDs during the original version of K448 after at least 30-s of exposure. Nonsignificant IED rate reductions were witnessed in all brain regions apart from the bilateral frontal cortices, where we observed increased frontal theta power during transitions from prolonged musical segments. All other presented musical stimuli were associated with nonsignificant IED alterations. These results suggest that the "Mozart K448 effect" is dependent on the duration of exposure and may preferentially modulate activity in frontal emotional networks, providing insight into the mechanism underlying this response. Our findings encourage the continued evaluation of Mozart's K448 as a noninvasive, non-pharmacological intervention for refractory epilepsy.
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Registered trials
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