ArticleNature communications2021
Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comparative effectiveness of antimicrobial implant surface coatings in preventing orthopaedic implant-associated infections: a network meta-analysis.Archives of orthopaedic and trauma surgery · 2026Pooled it
- Implants for fixation of intertrochanteric femoral fracture: a systematic review and network meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2025Pooled it
- Total femur replacement in revision arthroplasty for non-oncologic patients: a systematic review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Pooled it
- Electronic Chip-Mimetic Medical Implants for Controllable Sonothermal Treatments.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Metallothionein-Inspired Dual-Stage Ion-Regulatory Coatings With Infection-Triggered Bactericidal Activity and Long-Term Antifouling Protection.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Bioinspired and living multiscale composites for regenerative medicine in the treatment of surgical site infections.Journal of nanobiotechnology · 2026Review
- Quorum Sensing and Quorum Quenching in Pseudomonas aeruginosa and Staphylococcus aureus Infections: Therapeutic Potential, Limitations and Clinical Challenges.Antibiotics (Basel, Switzerland) · 2026Review
- A decoupling strategy toward spatiotemporal regulation and biomechanical transmission of sandwiched scaffold for osteochondral regeneration.Nature communications · 2026Article
- Immune and Stem Cell-Mediated Bactericidal Amplification and Bone Remodeling for Infection Clearance and Osteointegration.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Innovations in Implant Osseointegration: Biomaterials, Surface Engineering, and Translational Strategies.Journal of biomedical materials research. Part A · 2026Review
- Cannabis and nicotine use are independently associated with adverse surgical, medical, and psychosocial outcomes following upper extremity fracture fixation.Journal of orthopaedic surgery and research · 2026Article
- Tribological and antibacterial behavior of Cu doped DLC coatings for biomedical implants.Discover materials · 2026Article
- Metal-Organic Framework-Based Antimicrobial Touch Surfaces to Prevent Cross-Contamination.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Lead-free perovskite KCsSnIScientific reports · 2025Article
- Establishment of a clinically relevant beagle model for periprosthetic joint infection with 3D-printed prostheses and multimodal evaluation.Journal of orthopaedic translation · 2025Article
- Immobilization of KR-12 on a Titanium Alloy Surface Using Linking Arms Improves Antimicrobial Activity and Supports Osteoblast Cytocompatibility.ACS applied bio materials · 2025Article
- Anti-Methicillin-ResistantPolymers · 2025Article
- Current Strategies in Developing Antibacterial Surfaces for Joint Arthroplasty Implant Applications.Materials (Basel, Switzerland) · 2025Review
- Diamond-like carbon (DLC) surface treatment decreases biofilm burden by S. aureus on titanium alloy in vitro- a pilot study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- COVALENT GRAFTING OF TANFLOC ON TITANIA NANOTUBE ARRAYS: AN APPROACH TO MITIGATE BACTERIAL ADHESION AND IMPROVE THE ANTIBACTERIAL EFFICACY OF TITANIUM IMPLANTS.Advanced materials interfaces · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
Implant related infections are the most common cause of joint arthroplasty failure, requiring revision surgeries and a new implant, resulting in a cost of $8.6 billion annually. To address this problem, we created a class of coating technology that is applied in the operating room, in a procedure that takes less than 10 min, and can incorporate any desired antibiotic. Our coating technology uses an in situ coupling reaction of branched poly(ethylene glycol) and poly(allyl mercaptan) (PEG-PAM) polymers to generate an amphiphilic polymeric coating. We show in vivo efficacy in preventing implant infection in both post-arthroplasty infection and post-spinal surgery infection mouse models. Our technology displays efficacy with or without systemic antibiotics, the standard of care. Our coating technology is applied in a clinically relevant time frame, does not require modification of implant manufacturing process, and does not change the implant shelf life.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.