ArticleNature communications2021
Neofunctionalization of an ancient domain allows parasites to avoid intraspecific competition by manipulating host behaviour.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Enhanced biocontrol traits of Pachycrepoideus vindemmiae reared on the alternative host Drosophila virilis.Pest management science · 2026Article
- A bacterial gene acquired by parasitoid wasps contributes to venom secretion against host defence.The EMBO journal · 2026Article
- A Set of Novel Venom Proteins Enables Parasitoid Wasps to Exploit Older Hosts and Coexist with Competitors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Behavioral and physiological responses of the aphelinid parasitoid, Encarsia formosa, to interspecific competitors.Communications biology · 2025Article
- Multifaceted Defenses Against Parasitoid Wasps in Diptera.Annual review of genetics · 2025Review
- Duplication of a conserved mitochondrial enzyme gene arms parasitoid wasps with venom cytotoxicity and oogenesis regulation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A rare, evolutionarily conserved venom protein benefits endoparasitism across parasitoids.Cell genomics · 2025Article
- Evaluation of Pupal ParasitoidsInsects · 2025Article
- Assaying Nociception Behaviors inCold Spring Harbor protocols · 2025Article
- Chromosome-level genome sequencing and assembly of the parasitoid wasp Leptopilina myrica.Scientific data · 2025Article
- Encapsulation and Melanization Are Not Correlated to Successful Immune Defense Against Parasitoid Wasps inCells · 2025Article
- Article
- Histone deacetylase HDAC3 regulates ergosterol production for oxidative stress tolerance in the entomopathogenic and endophytic fungusmSystems · 2024Article
- Host and venom evolution in parasitoid wasps: does independently adapting to the same host shape the evolution of the venom gland transcriptome?BMC biology · 2024Article
- Coordinated molecular and ecological adaptations underlie a highly successful parasitoid.eLife · 2024Article
- Larval secretions of parasitoid wasps are new effectors that impair host immune defences.Crop health · 2023Article
- Comprehensive isoform-level analysis reveals the contribution of alternative isoforms to venom evolution and repertoire diversity.Genome research · 2023Article
- Effect of Ultraviolet-B RadiatingInsects · 2023Article
- The vitellogenin receptor gene contributes to mating and host-searching behaviors in parasitoid wasps.iScience · 2023Article
- Metabolomics Provides New Insights into Host Manipulation Strategies byMetabolites · 2023Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intraspecific competition is a major force in mediating population dynamics, fuelling adaptation, and potentially leading to evolutionary diversification. Among the evolutionary arms races between parasites, one of the most fundamental and intriguing behavioural adaptations and counter-adaptations are superparasitism and superparasitism avoidance. However, the underlying mechanisms and ecological contexts of these phenomena remain underexplored. Here, we apply the Drosophila parasite Leptopilina boulardi as a study system and find that this solitary endoparasitic wasp provokes a host escape response for superparasitism avoidance. We combine multi-omics and in vivo functional studies to characterize a small set of RhoGAP domain-containing genes that mediate the parasite's manipulation of host escape behaviour by inducing reactive oxygen species in the host central nervous system. We further uncover an evolutionary scenario in which neofunctionalization and specialization gave rise to the novel role of RhoGAP domain in avoiding superparasitism, with an ancestral origin prior to the divergence between Leptopilina specialist and generalist species. Our study suggests that superparasitism avoidance is adaptive for a parasite and adds to our understanding of how the molecular manipulation of host behaviour has evolved in this system.
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