ArticleNature communications2021
Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 23 citations in OpenAlex.
- Application of Resazurin and ATP Detection Cell Viability Assays for Drug Sensitivity Screening in Ewing Sarcoma.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Genetic and Epigenetic Manipulation Using CRISPR Techniques in Ewing Sarcoma.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Analysis of Colony Formation Capacity in Ewing Sarcoma.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Proliferation Assessment by Trypan Blue Exclusion in Ewing Sarcoma.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Proteomic landscape of Ewing sarcoma primary tumors and metastases.Nature communications · 2026Article
- PRC1 promotes immunosuppressive macrophages in sepsis via β-catenin/STAT3 signaling.Cellular and molecular life sciences : CMLS · 2026Article
- The hegemonic EWSR1::ETS oncoprotein overrules core regulatory circuitry principles in Ewing sarcoma.NPJ precision oncology · 2025Article
- BKT300: A Novel Anti-Leukemic Small Molecule Targeting the Protein Regulator of Cytokinesis 1 (PRC1) Pathway.Research square · 2025Article
- The Functional Transcriptomic Landscape Informs Therapeutic Strategies in Multiple Myeloma.Cancer research · 2025Article
- Large-scale genomic-wide CRISPR screening revealed PRC1 as a tumor essential candidate in clear cell renal cell carcinoma.International journal of medical sciences · 2025Article
- Druggable upregulated proteins in EWS-FLI-driven Ewing sarcoma as emerging new therapeutic targets.American journal of translational research · 2025Review
- Article
- Unlocking epigenetics for precision treatment of Ewing's sarcoma.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024Article
- Antiparallel microtubule bundling supports KIF15-driven mitotic spindle assembly.Molecular biology of the cell · 2024Article
- Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells.Frontiers in oncology · 2024Article
- Protein regulator of cytokinesis 1: a potential oncogenic driver.Molecular cancer · 2023Article
- Targeted Therapy for EWS-FLI1 in Ewing Sarcoma.Cancers · 2023Review
- Molecular and biologic biomarkers of Ewing sarcoma: A systematic review.Journal of bone oncology · 2023Review
- Identification of lncRNA, miRNA and mRNA expression profiles and ceRNA Networks in small cell lung cancer.BMC genomics · 2023Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 7 institutions in 2 countries.
Jing LiMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Shunya OhmuraMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Aruna MarchettoMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Martin F OrthMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Roland ImleHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0001-9564-6952
Marlene DallmayerMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Julian MusaMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Maximilian M L KnottMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.ORCID 0000-0002-6995-3702
Tilman L B HöltingMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.ORCID 0000-0001-5598-7330
Stefanie SteinMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Cornelius M FunkMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.ORCID 0000-0002-0837-3237
Ana SastreUnidad Hemato-oncología Pediátrica, Hospital Infantil Universitario La Paz, Madrid, Spain.
Javier AlonsoPediatric Solid Tumour Laboratory, Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0002-6287-8391
Felix BestvaterLight Microscopy Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Merve KasanMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Laura Romero-PérezMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.ORCID 0000-0003-3196-4382
Wolfgang HartmannDivision of Translational Pathology, Gerhard-Domagk-Institute for Pathology, University Hospital Münster, Münster, Germany.ORCID 0000-0002-7609-5021
Andreas RanftPediatrics III, AYA Unit, West German Cancer Centre, University Hospital Essen, Essen, Germany.
Ana BanitoHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Uta DirksenPediatrics III, AYA Unit, West German Cancer Centre, University Hospital Essen, Essen, Germany.ORCID 0000-0002-5435-7860
Thomas KirchnerMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Florencia Cidre-AranazMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.ORCID 0000-0002-0246-7179
Thomas G P GrünewaldMax-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. t.gruenewald@kitz-heidelberg.de.ORCID 0000-0003-0920-7377
German Cancer Research Center · DELudwig-Maximilians-Universität München · DEEssen University Hospital · DEUniversity Hospital Münster · DEDeutschen Konsortium für Translationale Krebsforschung · DEHospital Universitario La Paz · ESInstituto de Salud Carlos III · ES
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosomal instability (CIN) is a hallmark of cancer
Indexed as
AnimalsApoptosisCell Cycle ProteinsCell Line, TumorChildGene Expression ProfilingGene Expression Regulation, NeoplasticHEK293 CellsHumansKaplan-Meier EstimateMiceMice, Inbred NODMice, KnockoutMice, SCIDOncogene Proteins, FusionPolo-Like Kinase 1Cell Cycle ProteinsEWSR1-FLI1 fusion protein, humanOncogene Proteins, FusionPolo-Like Kinase 1PRC1 protein, humanProtein Serine-Threonine KinasesProto-Oncogene Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.