Observational studyNeurology2021
Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study.
Open access · greenAbstract readMulticenter StudyObservational Study
In one paragraph
Observational study in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 3 pooled it
6.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Cerebral amyloid angiopathy-related inflammation (CAA-ri): an updated systematic review and meta-analysis.Journal of neurology · 2026Pooled it
- European Stroke Organisation (ESO) guidelines on Primary Angiitis of the Central Nervous System (PACNS).European stroke journal · 2023Guideline
- Expression of matrix metalloproteinases in cerebral amyloid angiopathy-a systematic review.Frontiers in neurologyPooled it
- Early vs Delayed Steroid Treatment in Cerebral Amyloid Angiopathy-Related Inflammation: A Retrospective Cohort Study.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy-Related Inflammation.Annals of clinical and translational neurology · 2026Article
- Preclinical evaluation of [EJNMMI research · 2026Article
- Fluorescence spectroscopy and machine learning methods for detection of Alzheimer's disease from circulating white blood cells.Journal of Alzheimer's disease : JAD · 2026Article
- Anti-amyloid immunotherapy drives APOE4 specific increases in glial reactivity, perivascular immune activation, and ARIA-like events.bioRxiv : the preprint server for biology · 2026Article
- Iatrogenic cerebral amyloid angiopathy: neuroinflammation and implications for future therapies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Type I interferon drives T cell responses to amyloid beta in the central nervous system.Nature communications · 2026Article
- Drug-Induced Amyloid-Related Imaging Abnormalities: A Neurovascular Perspective on Risk Assessment.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Use of anti-amyloid-β monoclonal antibodies in persons with Down syndrome Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Sialylation patterns in cerebral amyloid angiopathy.Brain pathology (Zurich, Switzerland) · 2026Article
- Spatially resolved transcriptomic profiling identifies distinct signatures in parenchymal and vascular microenvironments in Alzheimer's Disease with Cerebral Amyloid Angiopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Review
- Anti-Aβ3-10 monoclonal antibody 7B8 improves cognitive function and protects the blood-brain barrier in APP/PS1 mice by regulating the HMGB-1/RAGE/NF-κB pathway.Frontiers in immunology · 2026Article
- Review
- Alzheimer Combination Therapies: Overview and Scenarios.The journal of prevention of Alzheimer's disease · 2025Review
- Cerebrospinal fluid biomarkers in cerebral amyloid angiopathy: insights from a clinical case series.Arquivos de neuro-psiquiatria · 2025Article
- The role for artificial intelligence in identifying combination therapies for Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2025Review
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
33 authors at 13 institutions in 6 countries.
Laura AntoliniFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0003-1040-4191
Jacopo C DiFrancescoFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-4102-1188
Marialuisa ZeddeFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Gianpaolo BassoFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-6245-9402
Andrea ArighiFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0003-2865-3970
Atsushi ShimaFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-3068-4621
Annachiara CagninFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-0635-4884
Massimo CauloFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-4507-2740
Roxana O CarareFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0001-6458-3776
Andreas CharidimouFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0001-5891-337X
Mario CirilloFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0001-5350-7700
Vincenzo Di LazzaroFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Carlo FerrareseFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Alessia GiossiFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Domenico InzitariFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Michela MarconFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Roberto MarconiFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Masafumi IharaFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-7102-4048
Ricardo NitriniFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-5721-1525
Berardino OrlandiFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0001-5463-8809
Alessandro PadovaniFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-0119-3639
Rosario PascarellaFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Francesco PeriniFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Giulia PeriniFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Maria SessaFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Elio ScarpiniFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-6395-2119
Fabrizio TagliaviniFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0003-1039-7315
Raffaella ValentiFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-4975-3754
Juan Francisco Vázquez-CostaFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-3043-7938
Alberto Villarejo-GalendeFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-6834-7620
Yuta HagiwaraFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-3420-4218
Nicole ZiliottoFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0003-1007-7266
Fabrizio PiazzaFrom the School of Medicine and Surgery (L.A., J.C.D., G.B., C.F., N.Z., F. Piazza), University of Milano-Bicocca, Monza; Neurology Unit (M.Z.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico Milano and University of Milan (A.A., E.S.), Italy; Kyoto University Graduate School of Medicine (A.S.), Japan; University of Padova (A.C.); University of Chieti (M. Caulo), Italy; University of Southampton (R.O.C.), UK; Department of Neurology (A.C.), Boston Medical Center, Boston University, MA; University of Campania "Luigi Vanvitelli" (M. Cirillo), Napoli; Università Campus Biomedico (V.D.L.), Rome; Azienda Socio Sanitaria Territoriale di Cremona (A.G.); Italian National Research Council (D.I.), University of Florence; Neuroscience Institute (D.I.), Pisa; S. Bortolo Hospital (M.M., F. Perini), Vicenza; Azienda USL Toscana sud est (R.M.), Grosseto, Italy; National Cerebral and Cardiovascular Center (M.I.), Osaka, Japan; University of São Paulo Medical School (R.N.), Brazil; S.S. Filippo and Nicola Hospital (B.O.), Avezzano; University of Brescia (A.P.); Neuroradiology Unit (R.P.), Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia; IRCCS Mondino Foundation and University of Pavia (G.P.); Ospedale Papa Giovanni XXIII (M.S.), Bergamo; Fondazione IRCCS "Carlo Besta" National Neurological Institute (F.T.), Milan, Italy; Azienda USL Toscana Centro (R.V.), Prato, Italy; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (J.F.V.-C.), Valencia; Hospital Universitario 12 de Octubre (A.V.-G.), Madrid, Spain; St. Marianna University School of Medicine (Y.H.), Kawasaki, Japan; and CAA and AD Translational Research and Biomarkers Laboratory (F. Piazza), PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. fabrizio.piazza@unimib.it.
University of Milano-Bicocca · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITAzienda Socio Sanitaria Territoriale di CremonaFondazione IRCCS Istituto Neurologico Carlo Besta · ITHospital Universitario 12 De Octubre · ESNational Cerebral and Cardiovascular Center · JPUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Florence · ITUniversity of Milan · ITUniversity of Pavia · ITUniversity of Southampton · GBUrology Foundation · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe goal of this work was to investigate the natural history and outcomes after treatment for spontaneous amyloid-related imaging abnormalities (ARIA)-like in cerebral amyloid angiopathy-related inflammation (CAA-ri).
methodsThis was a multicenter, hospital-based, longitudinal, prospective observational study of inpatients meeting CAA-ri diagnostic criteria recruited through the Inflammatory Cerebral Amyloid Angiopathy and Alzheimer's Disease βiomarkers International Network from January 2013 to March 2017. A protocol for systematic data collection at first-ever presentation and at subsequent in-person visits, including T1-weighted, gradient recalled echo-T2*, fluid-suppressed T2-weighted (fluid-attenuated inversion recovery), and T1 postgadolinium contrast-enhanced images acquired on 1.5T MRI, was used at the 3-, 6-, 12-, and 24-month follow-up. Centralized reads of MRIs were performed by investigators blinded to clinical, therapeutic, and time-point information. Main outcomes were survival, clinical and radiologic recovery, intracerebral hemorrhage (ICH), and recurrence of CAA-ri.
resultsThe study enrolled 113 participants (10.6% definite, 71.7% probable, and 17.7% possible CAA-ri). Their mean age was 72.9 years; 43.4% were female; 37.1% were DISCUSSION: These results from the largest longitudinal cohort registry of patients with CAA-ri support the transient and potentially relapsing inflammatory nature of the clinical-radiologic acute manifestations of the disease and the effectiveness of slow oral tapering off after IV corticosteroid pulse therapy in preventing recurrences. Our results highlight the importance of differential diagnosis for spontaneous ARIA-like events in β-amyloid-driven diseases, including treatment-related ARIA in patients with Alzheimer disease exposed to immunotherapy drugs.
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Cerebral Amyloid AngiopathyAgedCerebral HemorrhageCohort StudiesFemaleHumansInflammationLongitudinal StudiesMagnetic Resonance ImagingProspective Studies
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