Evidence map›Paper›PMID 34531280›Full record

ArticleeNeuro

Secreted Reporter Assay Enables Quantitative and Longitudinal Monitoring of Neuronal Activity.

Ana C Santos, Simone Chiola, Guang Yang, Aleksandr Shcheglovitov, Sungjin Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ana C SantosDepartment of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84112.
Simone ChiolaDepartment of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84112.
Guang YangDepartment of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84112.
Aleksandr ShcheglovitovDepartment of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84112.
Sungjin ParkDepartment of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84112 sungjin.park@neuro.utah.edu.ORCID 0000-0003-4430-3305

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Cellular and molecular mechanisms disrupted in 22q13 deletion syndrome and autismR01MH113670 · NIMH · UNIVERSITY OF UTAH · PI SHCHEGLOVITOV, OLEKSANDR · 2018 to 2022
$1.9M
Signaling mechanism for synapse formation and function regulated by the release of GPI-anchored synaptogenic factors from astrocytesR01NS102444 · NINDS · UNIVERSITY OF UTAH · PI PARK, SUNG JIN · 2017 to 2021
$1.7M
Predoctoral Interdepartmental Training Program in NeuroscienceT32NS076067 · NINDS · UNIVERSITY OF UTAH · PI KEEFE, KRISTEN A · 2011 to 2015
$1.1M
NCATS NIH HHS UL1 TR002538NIMH NIH HHS R01 MH113670NINDS NIH HHS R01 NS102444NINDS NIH HHS T32 NS076067
6 · The paper itself

Abstract

The ability to measure changes in neuronal activity in a quantifiable and precise manner is of fundamental importance to understand neuron development and function. Repeated monitoring of neuronal activity of the same population of neurons over several days is challenging and, typically, low-throughput. Here, we describe a new biochemical reporter assay that allows for repeated measurements of neuronal activity in a cell type-specific manner. We coupled activity-dependent elements from the

Indexed as

NeuronsReceptors, N-Methyl-D-AspartateAnimalsFemaleGenes, ReporterLuciferasesMaleMiceSignal TransductionLuciferasesReceptors, N-Methyl-D-AspartateArc drivercalciumlive cell assayneuronal activity reporterNMDARsecreted reporter

Identifiers

PMID34531280
PMCPMC8489021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.