Evidence map›Paper›PMID 34531274›Full record

Trial reportThe European respiratory journal2021

BAY 2253651 for the treatment of obstructive sleep apnoea: a multicentre, double-blind, randomised controlled trial (SANDMAN).

Thomas Gaisl, Chris D Turnbull, Gerrit Weimann, Sigrun Unger, Rudolf Finger, Charles Xing, Peter A Cistulli, Sophie West, Alan K I Chiang, Danny J Eckert and 2 more

Registry-linked trialAbstract readLetterMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05527457 (Effects of BAY2586116 on Obstructive Sleep Apnoea), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05527457 phase1completednot on this mapstarted 2022, after this paper: background citation

Effects of BAY2586116 on Obstructive Sleep Apnoea (OSA) Severity Informed by Upper Airway Physiology and the Role of Route of Breathing

TypeinterventionalSponsorFlinders UniversityRan2022 to 2022Enrolled10ConditionsSleep Apnea, ObstructiveArmsBAY2586116, Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Thomas GaislSleep Disorders Center and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-9017-6143
Chris D TurnbullNational Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Gerrit WeimannClinical Experimentation, Pharma Research Center, Bayer Pharma, Wuppertal, Germany.
Sigrun UngerClinical Operations, Pharma Research Center, Bayer Pharma, Wuppertal, Germany.
Rudolf FingerClinical Operations, Pharma Research Center, Bayer Pharma, Wuppertal, Germany.
Charles XingGlobal Development, Bayer Healthcare Company, Beijing, China.
Peter A CistulliSleep Research Group, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Sophie WestNewcastle Regional Sleep Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Alan K I ChiangNeuroscience Research Australia (NeuRA), Sydney, Australia.ORCID 0000-0002-9156-0534
Danny J EckertAdelaide Institute for Sleep Health, Flinders health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia.ORCID 0000-0003-3503-2363
John R StradlingNational Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Malcolm KohlerSleep Disorders Center and Pulmonary Division, University Hospital Zurich, Zurich, Switzerland malcolm.kohler@usz.ch.

Funding

Department of Health
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Sleep Apnea, ObstructiveContinuous Positive Airway PressureDouble-Blind MethodHumans

Identifiers

PMID34531274
PMCPMC8607905

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.