Evidence map›Paper›PMID 34531263›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

A Guide to ComBat Harmonization of Imaging Biomarkers in Multicenter Studies.

Fanny Orlhac, Jakoba J Eertink, Anne-Ségolène Cottereau, Josée M Zijlstra, Catherine Thieblemont, Michel Meignan, Ronald Boellaard, Irène Buvat

Abstract readMulticenter Study
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 216 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

216 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. IsEuropean journal of nuclear medicine and molecular imaging · 2026
    Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Deep integration of clinical metadata with [European journal of nuclear medicine and molecular imaging · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Applications of artificial intelligence in nuclear medicine.Zeitschrift fur medizinische Physik · 2026
    Review
  18. Article
  19. Article
  20. Article

156 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Fanny OrlhacLITO-U1288, Institut Curie, Université PSL, Université Paris-Saclay, Inserm, Orsay, France; orlhacf@gmail.com.
Jakoba J EertinkAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Hematology, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Anne-Ségolène CottereauLITO-U1288, Institut Curie, Université PSL, Université Paris-Saclay, Inserm, Orsay, France.
Josée M ZijlstraAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Hematology, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Catherine ThieblemontDepartment of Hemato-Oncology, Hôpital Saint-Louis, DMU DHI, Université de Paris, APHP, Paris, France.
Michel MeignanLysa Imaging, Hôpital Henri Mondor, Université Paris-Est, APHP, Créteil, France; and.
Ronald BoellaardAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Radiology and Nuclear Medicine, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Irène BuvatLITO-U1288, Institut Curie, Université PSL, Université Paris-Saclay, Inserm, Orsay, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of PET image acquisition and reconstruction parameters on SUV measurements or radiomic feature values is widely documented. This scanner effect is detrimental to the design and validation of predictive or prognostic models and limits the use of large multicenter cohorts. To reduce the impact of this scanner effect, the ComBat method has been proposed and is now used in various contexts. The purpose of this article is to explain and illustrate the use of ComBat based on practical examples. We also give examples in which the ComBat assumptions are not met and, thus, in which ComBat should not be used.

Indexed as

Positron-Emission TomographyTomography, X-Ray ComputedBiomarkersImage Processing, Computer-AssistedPrognosisBiomarkersharmonizationmulticenter studiesradiomicstexture analysis

Identifiers

PMID34531263
PMCPMC8805779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.