Evidence map›Paper›PMID 34531156›Full record

ArticleJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2022

Indoor air pollution exposure is associated with greater morbidity in cystic fibrosis.

Sara W Carson, Kevin Psoter, Kirsten Koehler, Karen R Siklosi, Kristina Montemayor, Alexandra Toporek, Natalie E West, Noah Lechtzin, Nadia N Hansel, Joseph M Collaco and 1 more

Abstract read
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In one paragraph

Article in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Lung function and secondhand smoke exposure among children with cystic fibrosis: A Bayesian meta-analysis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Indoor air pollution and airway health.The Journal of allergy and clinical immunology · 2024
    Review
  6. Review
  7. Modifier Factors of Cystic Fibrosis Phenotypes: A Focus on Modifier Genes.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sara W CarsonDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States. Electronic address: scarson6@jhmi.edu.
Kevin PsoterDepartment of Pediatrics, Division of General Pediatrics, Johns Hopkins University, Baltimore, MD, United States.
Kirsten KoehlerDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Karen R SiklosiDepartment of Pediatrics, Division of Pulmonology, Johns Hopkins University, Baltimore, MD, United States.
Kristina MontemayorDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States.
Alexandra ToporekDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States.
Natalie E WestDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States.
Noah LechtzinDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States.
Nadia N HanselDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States.
Joseph M CollacoDepartment of Pediatrics, Division of Pulmonology, Johns Hopkins University, Baltimore, MD, United States.
Christian A MerloDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Funding

Gene-Environment Interactions in Cystic Fibrosis Lung DiseaseR01HL128475 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI COLLACO, JOSEPH MICHAEL · 2016 to 2019
$1.1M
Indoor Air Pollution and Outcomes in Cystic FibrosisF32HL149262 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CARSON, SARA WELLER · 2020 to 2020
$87k
NHLBI NIH HHS F32 HL149262NHLBI NIH HHS R01 HL128475
6 · The paper itself

Abstract

backgroundExposure to higher levels of outdoor air pollution is associated with increased morbidity in individuals with cystic fibrosis. Limited information exist regarding the potential adverse effects of indoor air pollution on those with cystic fibrosis.

methodsIndividuals with cystic fibrosis who were enrolled in the Twin and Sibling Study from 2000-2013, self-reported exposure to four known sources of indoor air pollution (secondhand smoke, forced hot air, wood stove and fireplace). Change in lung function, rates of hospitalizations and pulmonary exacerbations were followed over 4 years to compare outcomes in those who were exposed to those who were not exposed.

resultsOf 1432 participants with data on secondhand smoke exposure, 362 (25.3%) were exposed. Of 765 individuals with data on forced hot air exposure, 491 (64.2%) were exposed. Of 1247 participants with data on wood stove exposure and 830 with data on fireplace exposure, 182 (14.6%) and 373 (44.9%) were exposed, respectively. In longitudinal analysis, pediatric individuals either exposed to secondhand smoke or to forced hot air had a 0.60% predicted/year decrease in FEV

conclusionsOur questionnaire-based data suggest that exposure to sources of indoor air pollution increase morbidity in both the pediatric and adult cystic fibrosis populations. Future studies with quantitative indoor air quality assessments are needed.

Indexed as

Air Pollution, IndoorCystic FibrosisTobacco Smoke PollutionAdultChildHumansLungMorbidityTobacco Smoke PollutionIndoor air qualityObstructive lung diseaseSecondhand smoke

Identifiers

PMID34531156
PMCPMC8918065

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.