Evidence map›Paper›PMID 34530997›Full record

ArticleGene2019

Putative circumsporozoite protein (CSP) of Plasmodium vivax is considerably distinct from the well-known CSP and plays a role in the protein ubiquitination pathway.

Manoswini Dash, Veena Pande, Abhinav Sinha

Abstract read
PubMed Publisher
In one paragraph

Article in Gene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Ubiquitin-proteasome system inFrontiers in medicine · 2024
    Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Manoswini DashDivision of Epidemiology and Clinical Research, ICMR-National Institute of Malaria Research, New Delhi, India.
Veena PandeDepartment of Biotechnology, Bhimtal Campus, Kumaun University, Nainital, Uttarakhand, India.
Abhinav SinhaDivision of Epidemiology and Clinical Research, ICMR-National Institute of Malaria Research, New Delhi, India. Electronic address: abhinav@mrcindia.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amidst technical challenges which limit successful culture and genetic manipulation of P. vivax parasites, we used a computational approach to identify a critical target with evolutionary significance. The putative circumsporozoite protein on chromosome 13 of P. vivax (PvpuCSP)is distinct from the well-known vaccine candidate PfCSP. The aim of this study was to understand the role of PvpuCSP and its relatedness to the well-known CSP. The study revealed PvpuCSP as a membrane bound E3 ubiquitin ligase involved in ubiquitination. It has a species-specific tetra-peptide unit which is differentially repeated in various P. vivax strains. The PvpuCSP is different from CSP in terms of stage-specific expression and function. Since E3 ubiquitin ligases are known antimalarial drug targets targeting the proteasome pathway, PvpuCSP, with evolutionary connotation and a key role in orchestrating protein degradation in P. vivax, can be explored as a potential drug target.

Indexed as

Circumsporozoite proteinComputational analysisHypothetical proteinMalariaPlasmodium vivaxTandem repeat

Identifiers

PMID34530997

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.