Evidence map›Paper›PMID 34530994›Full record

ArticleGene2019

Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain.

Ana Segura, Pura Ballester, Raquel Ajo, María-Del-Mar Inda, Antonio Urbano, Javier Muriel, Isabel Ochando, César Margarit, Emi Martinez, Ana M Peiró

Abstract read
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In one paragraph

Article in Gene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Ana SeguraAndrology Unit, University General Hospital of Alicante (HGUA), Alicante, Spain; Neuropharmacology on Pain Research Unit, Institute of Health and Biomedical Research of Alicante (ISABIAL-FISABIO), Alicante, Spain.
Pura BallesterNeuropharmacology on Pain Research Unit, Institute of Health and Biomedical Research of Alicante (ISABIAL-FISABIO), Alicante, Spain.
Raquel AjoNeuropharmacology on Pain Research Unit, Institute of Health and Biomedical Research of Alicante (ISABIAL-FISABIO), Alicante, Spain.
María-Del-Mar IndaNeuropharmacology on Pain Research Unit, Institute of Health and Biomedical Research of Alicante (ISABIAL-FISABIO), Alicante, Spain.
Antonio UrbanoGenetics Unit, Clínica Vistahermosa HLA-Hospital, Alicante, Spain; Histology and Anatomy Department, Miguel Hernández University (UMH), Alicante, Spain.
Javier MurielNeuropharmacology on Pain Research Unit, Institute of Health and Biomedical Research of Alicante (ISABIAL-FISABIO), Alicante, Spain; Occupational Observatory, University Miguel Hernández of Elche (UMH), Alicante, Spain.
Isabel OchandoGenetics Unit, Clínica Vistahermosa HLA-Hospital, Alicante, Spain; Histology and Anatomy Department, Miguel Hernández University (UMH), Alicante, Spain.
César MargaritNeuropharmacology on Pain Research Unit, Institute of Health and Biomedical Research of Alicante (ISABIAL-FISABIO), Alicante, Spain; Pain Unit, HGUA, Alicante, Spain.
Emi MartinezPain Unit, HGUA, Alicante, Spain.
Ana M PeiróNeuropharmacology on Pain Research Unit, Institute of Health and Biomedical Research of Alicante (ISABIAL-FISABIO), Alicante, Spain; Clinical Pharmacology, HGUA, Alicante, Spain. Electronic address: peiro_ana@gva.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards. SUBJECT PATIENTS/

methodsThe study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software.

resultsA total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients.

conclusionT786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards.

Indexed as

Chronic paineNOS geneErectile dysfunctioniPDE5PharmacogeneticsT786C

Identifiers

PMID34530994

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.