Evidence map›Paper›PMID 34530989›Full record

ArticleGene2019

Analysis of RAMP3 gene polymorphism with body composition and bone density in young and elderly women.

Jai Prakash, Maria Herlin, Jitender Kumar, Gaurav Garg, Kristina E Akesson, Peter S Grabowski, Tim M Skerry, Gareth O Richards, Fiona E A McGuigan

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Article in Gene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jai PrakashLund University, Dept. of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, Sweden.
Maria HerlinLund University, Dept. of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, Sweden; Dept. of Environmental Research and Monitoring, Swedish Museum of Natural History, Stockholm, Sweden.
Jitender KumarAmity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, India.
Gaurav GargGenomics Division, LCGC Life sciences LLP, New Delhi, India.
Kristina E AkessonLund University, Dept. of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, Sweden; Skåne University Hospital, Dept. of Orthopedics, Malmö, Sweden.
Peter S GrabowskiHuman Nutrition Unit, Dept. of Oncology and Metabolism, Sheffield University, UK.
Tim M SkerryAcademic Unit of Bone Biology, Dept. of Oncology and Metabolism, Sheffield University, UK.
Gareth O RichardsAcademic Unit of Bone Biology, Dept. of Oncology and Metabolism, Sheffield University, UK.
Fiona E A McGuiganLund University, Dept. of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, Sweden. Electronic address: fiona.mcguigan@med.lu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimThe Receptor Activity Modifying Proteins (RAMPs) are a group of accessory proteins, of which there are three in humans, that interact with a number of G-protein coupled receptors (GPCR) and play various roles in regulation of endocrine signaling. Studies in RAMP3 knockout (KO) mice reveal an age related phenotype with altered metabolic regulation and high bone mass. To translate these findings into a clinically relevant perspective, we investigated the association between RAMP3 gene variants, body composition and bone phenotypes in two population-based cohorts of Swedish women.

methodsFive single nucleotide polymorphisms (SNP) in the vicinity of the RAMP3 gene were genotyped in the PEAK-25 cohort (n = 1061; 25 years) and OPRA (n = 1044; 75 years). Bone mineral density (BMD), fat mass and lean mass (total body; regional) were measured by DXA at baseline, 5 and 10 year follow-up.

resultsBMD did not differ with RAMP3 genotype in either cohort, although fracture risk was increased in the elderly women (OR 2.695 [95% CI 1.514-4.801]). Fat mass tended to be higher with RAMP3 SNPs; although only in elderly women. In the young women, changes in BMI and fat mass between ages 25-35 differed by genotype (p = 0.001; p < 0.001).

conclusionVariation in RAMP3 may contribute to age-related changes in body composition and risk of fracture.

Indexed as

BMDFatFractureRAMP3SNP

Identifiers

PMID34530989

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