Evidence map›Paper›PMID 34530988›Full record

ArticleGene2019

Characterization of paralogous uncx transcription factor encoding genes in zebrafish.

Valeria Nittoli, Antonio Emidio Fortunato, Giulia Fasano, Ugo Coppola, Alessandra Gentile, Sylvie Maiella, Fernanda Langellotto, Immacolata Porreca, Raffaella De Paolo, Rita Marino and 9 more

Abstract read
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In one paragraph

Article in Gene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Valeria NittoliBiology and Evolution of Marine Organisms, Zoological Station Anton Dohrn, 80121 Naples, Italy.
Antonio Emidio FortunatoImmunrise Technologies, 75005 Paris, France.
Giulia FasanoBiology and Evolution of Marine Organisms, Zoological Station Anton Dohrn, 80121 Naples, Italy.
Ugo CoppolaBiology and Evolution of Marine Organisms, Zoological Station Anton Dohrn, 80121 Naples, Italy.
Alessandra GentileDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.
Sylvie MaiellaOrphanet, French National Institute for Health and Medical Research, 75014 Paris, France.
Fernanda LangellottoWyss Institute for Biologically Inspired Engineering at Harvard University, 02115 Boston, USA.
Immacolata PorrecaHuman Genetics,Wellcome Sanger Institute, CB10 1SA Hinxton, UK.
Raffaella De PaoloBiology and Evolution of Marine Organisms, Zoological Station Anton Dohrn, 80121 Naples, Italy.
Rita MarinoBiology and Evolution of Marine Organisms, Zoological Station Anton Dohrn, 80121 Naples, Italy.
Marcella FiengoDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Aldo DonizettiDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Francesco AnielloDepartment of Biology, University of Naples Federico II, 80126 Naples, Italy.
Takashi KondoLaboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 230-0045 Yokohama, Japan.
Filomena RistoratoreBiology and Evolution of Marine Organisms, Zoological Station Anton Dohrn, 80121 Naples, Italy.
Lorella M T CanzonieroDepartment of Science and Technology, University of Sannio, 82100 Benevento, Italy.
Denis DubouleSchool of Life Sciences, Federal Institute of Technology, 1015 Lausanne, Switzerland; University of Geneva, 1205 Geneva, Switzerland.
Stephen W WilsonDepartment of Cell and Developmental Biology, University College London, WC1E6BT London, UK.
Paolo SordinoBiology and Evolution of Marine Organisms, Zoological Station Anton Dohrn, 80121 Naples, Italy. Electronic address: paolo.sordino@szn.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The paired-type homeodomain transcription factor Uncx is involved in multiple processes of embryogenesis in vertebrates. Reasoning that zebrafish genes uncx4.1 and uncx are orthologs of mouse Uncx, we studied their genomic environment and developmental expression. Evolutionary analyses indicate the zebrafish uncx genes as being paralogs deriving from teleost-specific whole-genome duplication. Whole-mount in situ mRNA hybridization of uncx transcripts in zebrafish embryos reveals novel expression domains, confirms those previously known, and suggests sub-functionalization of paralogs. Using genetic mutants and pharmacological inhibitors, we investigate the role of signaling pathways on the expression of zebrafish uncx genes in developing somites. In identifying putative functional role(s) of zebrafish uncx genes, we hypothesized that they encode transcription factors that coordinate growth and innervation of somitic muscles.

Indexed as

DevelopmentSignaling pathwaySyntenyTSGDUncxZebrafish

Identifiers

PMID34530988

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.