Evidence map›Paper›PMID 34530842›Full record

ArticleJournal of neuroinflammation2021

1α,25-dihydroxyvitamin D

Francesca Lazzara, Rosario Amato, Chiara Bianca Maria Platania, Federica Conti, Tsung-Han Chou, Vittorio Porciatti, Filippo Drago, Claudio Bucolo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Francesca Lazzara *Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, School of Medicine, University of Catania, Catania, Italy.
Rosario Amato *Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Chiara Bianca Maria PlataniaDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology, School of Medicine, University of Catania, Catania, Italy.
Federica ContiDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology, School of Medicine, University of Catania, Catania, Italy.
Tsung-Han ChouBascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Vittorio PorciattiBascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Filippo DragoDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology, School of Medicine, University of Catania, Catania, Italy.
Claudio BucoloDepartment of Biomedical and Biotechnological Sciences, Section of Pharmacology, School of Medicine, University of Catania, Catania, Italy. claudio.bucolo@unict.it.ORCID http://orcid.org/0000-0002-4879-4140
University of Catania · ITUniversity of Miami · USUniversity of Pisa · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca E62C17000000006
6 · The paper itself

Abstract

backgroundGlaucoma is an optic neuropathy characterized by loss of function and death of retinal ganglion cells (RGCs), leading to irreversible vision loss. Neuroinflammation is recognized as one of the causes of glaucoma, and currently no treatment is addressing this mechanism. We aimed to investigate the anti-inflammatory and neuroprotective effects of 1,25(OH)

methodsDBA/2J mice were randomized to 1,25(OH)

resultsDBA/2J mice treated with 1,25(OH)

conclusions1,25(OH)

Indexed as

AnimalsCalcitriolCalcium-Regulating Hormones and AgentsFemaleGene Regulatory NetworksGlaucomaMiceMice, Inbred DBAMice, TransgenicNeuroprotective AgentsRetinal Ganglion CellsCalcitriolCalcium-Regulating Hormones and AgentsNeuroprotective AgentsCalcitriolCytokinesGlaucomaInflammationRetinaVitamin D

Identifiers

PMID34530842
PMCPMC8444391
OpenAlexW3199386796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.