ArticleBMC neurology2021
Decreased nocturnal heart rate variability and potentially related brain regions in arteriosclerotic cerebral small vessel disease.
Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- Ultra-widefield OCTA assessment of retinal and choroidal microcirculation in cerebral small vessel disease.Scientific reports · 2026Article
- Association between minimum nocturnal heart rate and cerebral small vessel disease in patients with obstructive sleep apnea.Frontiers in aging neuroscience · 2026Article
- Heart Rate Variability Applications in Medical Specialties: A Narrative Review.Applied psychophysiology and biofeedback · 2025Review
- Relationship between cortical activation and sleep quality in cerebral small vessel disease patients: a functional near-infrared spectroscopy (fNIRS) study.Frontiers in neurology · 2025Article
- Different implications of daytime and nighttime heart rate variability on total burden of cerebral small vascular disease in patients with nondisabling ischemic cerebrovascular events.Frontiers in cardiovascular medicine · 2024Article
- Implication of heart rate variability on cerebral small vessel disease: A potential therapeutic target.CNS neuroscience & therapeutics · 2023Article
- Differences in Gray Matter Volume in Cerebral Small Vessel Disease Patients with and without Sleep Disturbance.Brain sciences · 2023Article
- The Hemisphere of the Brain in Which a Stroke Has Occurred Visible in the Heart Rate Variability.Life (Basel, Switzerland) · 2022Article
- Sleep as a window of cardiometabolic health: The potential of digital sleep and circadian biomarkers.Digital healthReview
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo assess heart rate variability (HRV) among patients with arteriosclerotic cerebral small vessel disease (CSVD) by comparing with control subjects, and to determine whether HRV parameters were related to structural alterations in brain regions involved in autonomic regulation among CSVD patients.
methodsWe consecutively recruited subjects aged between 50 and 80 years who visited the Stroke Prevention Clinic of our hospital and have completed brain magnetic resonance imaging examination from September 1, 2018 to August 31, 2019. Polysomnography and synchronous analyses of HRV were then performed in all participants. Multivariable binary logistic regression was used to identify the relationship between HRV parameters and CSVD. Participants were invited to further undergo three-dimensional brain volume scan, and the voxel based morphometry (VBM) analysis was used to identify gray matter atrophy.
resultsAmong 109 participants enrolled in this study, 63 were assigned to the arteriosclerotic CSVD group and 46 to the control group. Lower standard deviation of normal-to-normal intervals (SDNN, OR = 0.943, 95% CI 0.903 to 0.985, P = 0.009) and higher ratio of low to high frequency power (LF/HF, OR = 4.372, 95% CI 1.033 to 18.508, P = 0.045) during the sleep period were associated with CSVD, independent of traditional cerebrovascular risk factors and sleep disordered breathing. A number of 24 CSVD patients and 21 controls further underwent three-dimensional brain volume scan and VBM analysis. Based on VBM results, SDNN during the awake time (β = 0.544, 95% CI 0.211 to 0.877, P = 0.001) and the sleep period (β = 0.532, 95% CI 0.202 to 0.862, P = 0.001) were both positively related with gray matter volume within the right inferior frontal gyrus only among CSVD patients.
conclusionsDecreased nocturnal HRV is associated with arteriosclerotic CSVD independent of traditional cerebrovascular risk factors and sleep disordered breathing. The structural atrophy of some brain regions associated with cardiac autonomic regulation sheds light on the potential relationship.
trial registrationTrial registration number: ChiCTR1800017902 . Date of registration: 20 Aug 2018.
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