Evidence map›Paper›PMID 34529798›Full record

SynthesisThe Journal of antimicrobial chemotherapy2021

Efficacy of doxycycline versus azithromycin for the treatment of rectal chlamydia: a systematic review and meta-analysis.

Liang-Fu Chen, Ting-Cheng Wang, Fu-Lun Chen, Shih-Chang Hsu, Chin-Wang Hsu, Chyi-Huey Bai, Yuan-Pin Hsu

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The Journal of antimicrobial chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Zoonotic transmission ofNew microbes and new infections · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Liang-Fu ChenEmergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0003-1052-6156
Ting-Cheng WangEmergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Fu-Lun ChenDepartment of Internal Medicine, Division of Infectious Diseases, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Shih-Chang HsuEmergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Chin-Wang HsuEmergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Chyi-Huey BaiDepartment of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Yuan-Pin HsuEmergency Department, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Wan Fang Hospital · TWTaipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChlamydia trachomatis infection is the most common sexually transmitted infectious disease and carries a risk of complications. However, the optimal treatment for rectal chlamydial infection remains unclear.

objectivesTo compare the efficacy of doxycycline and azithromycin for the treatment of rectal chlamydia by undertaking a systematic review and meta-analysis of published data.

methodsWe searched PubMed, EMBASE, Cochrane Library, Web of Science and clinicaltrials.gov databases from inception to 7 July 2021 for randomized controlled trials (RCTs) and observational studies that compared the efficacy of doxycycline and single-dose azithromycin on rectal chlamydia cure rates. Data were synthesized using a random-effects model, and subgroup analysis was conducted.

resultsAll included studies were conducted in developed countries. Two RCTs and nine observational studies, with a total of 2457 patients, were analysed. Doxycycline had a higher microbiological cure rate than azithromycin (risk ratio = 1.21; 95% CI = 1.15-1.28; P < 0.05). Pooled results from two RCTs also revealed a higher microbiological cure rate for doxycycline than azithromycin (risk ratio = 1.27; 95% CI = 1.20-1.35; P < 0.05). The results remained consistent in subgroups of different study designs, countries and sexes.

conclusionsOn the basis of our findings, we recommend doxycycline rather than azithromycin as a first-line treatment for rectal chlamydia in developed countries. More RCTs from developing countries are warranted.

Indexed as

AzithromycinChlamydia InfectionsAnti-Bacterial AgentsChlamydia trachomatisDoxycyclineHumansAnti-Bacterial AgentsAzithromycinDoxycycline

Identifiers

PMID34529798
OpenAlexW3201621658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.