ArticlePloS one2021
Genetic differentiation of mainland-island sheep of Greece: Implications for identifying candidate genes for long-term local adaptation.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Article
- Genomic insights into Greek sheep structure and admixture with global domestic breeds.BMC genomics · 2026Article
- Comparative Whole Genome Analysis and Targeted Validation of Variants in Three Greek Indigenous Sheep Breeds.Current issues in molecular biology · 2026Article
- Potential Applications of Genome-Wide Association Studies in Establishing Climate Resilience in Livestock: A Comprehensive Review.International journal of molecular sciences · 2026Review
- Genetic Diversity, Population Structure, and Historical Gene Flow Patterns of Nine Indigenous Greek Sheep Breeds.Biology · 2025Article
- Genome-Wide Association Study (GWAS) on Reproductive Seasonality in Indigenous Greek Sheep Breeds: Insights into Genetic Integrity.Current issues in molecular biology · 2025Article
- Applications of Next-Generation Sequencing Technologies and Statistical Tools in Identifying Pathways and Biomarkers for Heat Tolerance in Livestock.Veterinary sciences · 2024Review
- Genetic diversity of United States Rambouillet, Katahdin and Dorper sheep.Genetics, selection, evolution : GSE · 2024Article
- Genome-Wide Association Study of Body Conformation Traits in Tashi Goats (Animals : an open access journal from MDPI · 2024Article
- A Combined Approach for the Characterization of Small Ruminant Lentivirus Strains Circulating in the Islands and Mainland of Greece.Animals : an open access journal from MDPI · 2024Article
- Genomics of founders for conservation breeding: the Jasper caribou case.Conservation genetics (Print) · 2023Article
- Runs of Homozygosity Uncover Potential Functional-Altering Mutation Associated With Body Weight and Length in Two Duroc Pig Lines.Frontiers in veterinary science · 2022Article
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Authors and funding
6 authors.
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Abstract
In Greece, a number of local sheep breeds are raised in a wide range of ecological niches across the country. These breeds can be used for the identification of genetic variants that contribute to local adaptation. To this end, 50k genotypes of 90 local sheep from mainland Greece (Epirus, n = 35 and Peloponnesus, n = 55) were used, as well as 147 genotypes of sheep from insular Greece (Skyros, n = 21), Lemnos, n = 36 and Lesvos, n = 90). Principal components and phylogenetic analysis along with admixture and spatial point patterns analyses suggested genetic differentiation of 'mainland-island' populations. Genome scans for signatures of selection and genome-wide association analysis (GWAS) pointed to one highly differentiating marker on OAR4 (FST = 0.39, FLK = 21.93, FDR p-value = 0.10) that also displayed genome wide significance (FDR p-value = 0.002) during GWAS. A total number of 6 positional candidate genes (LOC106990429, ZNF804B, TEX47, STEAP4, SRI and ADAM22) were identified within 500 kb flanking regions around the significant marker. In addition, two QTLs related to fat tail deposition are reported in genomic regions 800 kb downstream the significant marker. Based on gene ontology analysis and literature evidence, the identified candidate genes possess biological functions relevant to local adaptation that worth further investigation.
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