ArticlePLoS biology2021
Prefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation.
Article in PLoS biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Sleep forms flexible context representations in toddlers.Nature communications · 2026Article
- The hippocampus as a generative model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Distinct goal location beta frequency dynamics in hippocampus and prefrontal cortex across learning.bioRxiv : the preprint server for biology · 2026Article
- New information triggers prospective codes to adapt for flexible navigation.Nature communications · 2025Article
- Article
- Closed-loop modulation of remote hippocampal representations with neurofeedback.bioRxiv : the preprint server for biology · 2024Article
- Integration of rate and phase codes by hippocampal cell-assemblies supports flexible encoding of spatiotemporal context.Nature communications · 2024Article
- Goal Choices Modify Frontotemporal Memory Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neural ensembles in navigation: From single cells to population codes.Current opinion in neurobiology · 2023Review
- Imagination as a fundamental function of the hippocampus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Context-independent expression of spatial code in hippocampus.Scientific reports · 2022Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The receptive field of a neuron describes the regions of a stimulus space where the neuron is consistently active. Sparse spiking outside of the receptive field is often considered to be noise, rather than a reflection of information processing. Whether this characterization is accurate remains unclear. We therefore contrasted the sparse, temporally isolated spiking of hippocampal CA1 place cells to the consistent, temporally adjacent spiking seen within their spatial receptive fields ("place fields"). We found that isolated spikes, which occur during locomotion, are strongly phase coupled to hippocampal theta oscillations and transiently express coherent nonlocal spatial representations. Further, prefrontal cortical activity is coordinated with and can predict the occurrence of future isolated spiking events. Rather than local noise within the hippocampus, sparse, isolated place cell spiking reflects a coordinated cortical-hippocampal process consistent with the generation of nonlocal scenario representations during active navigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.