Evidence map›Paper›PMID 34529475›Full record

ArticleScience (New York, N.Y.)2021

Response to Comments on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections".

Timothy J Break, Vasileios Oikonomou, Nicolas Dutzan, Jigar V Desai, Marc Swidergall, Tilo Freiwald, Daniel Chauss, Oliver J Harrison, Julie Alejo, Drake W Williams and 33 more

Open access · greenAbstract readComment
In one paragraph

Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Thymic inborn errors of immunity.The Journal of allergy and clinical immunology · 2025
    Review
  3. Review
  4. A deep intronic splice-alteringScience translational medicine · 2024
    Article
  5. Review
  6. Review
  7. Review
  8. Infections in the monogenic autoimmune syndrome APECED.Current opinion in immunology · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

43 authors at 15 institutions in 4 countries.

Timothy J BreakFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, USA.
Vasileios OikonomouFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, USA.
Nicolas DutzanOral Immunity and Inflammation Section, National Institute of Dental and Craniofacial Research (NIDCR), Bethesda, MD, USA.
Jigar V DesaiFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, USA.
Marc SwidergallLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Tilo FreiwaldImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD, USA.
Daniel ChaussImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD, USA.
Oliver J HarrisonMetaorganism Immunity Section, Laboratory of Immune System Biology, NIAID, Bethesda, MD, USA.
Julie AlejoLaboratory of Pathology, Center for Cancer Research, National Cancer Institute (NCI), Bethesda, MD, USA.
Drake W WilliamsOral Immunity and Inflammation Section, National Institute of Dental and Craniofacial Research (NIDCR), Bethesda, MD, USA.
Stefania PittalugaLaboratory of Pathology, Center for Cancer Research, National Cancer Institute (NCI), Bethesda, MD, USA.
Chyi-Chia R LeeLaboratory of Pathology, Center for Cancer Research, National Cancer Institute (NCI), Bethesda, MD, USA.
Nicolas BouladouxMetaorganism Immunity Section, Laboratory of Immune System Biology, NIAID, Bethesda, MD, USA.
Muthulekha SwamydasFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, USA.
Kevin W HoffmanDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Teresa Greenwell-WildOral Immunity and Inflammation Section, National Institute of Dental and Craniofacial Research (NIDCR), Bethesda, MD, USA.
Vincent M BrunoInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Lindsey B RosenImmunopathogenesis Section, LCIM, NIAID, Bethesda, MD, USA.
Wint LwinDiabetes Center, University of California, San Francisco, CA, USA.
Andy RenteriaFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, USA.
Sergio M PontejoMolecular Signaling Section, Laboratory of Molecular Immunology, NIAID, Bethesda, MD, USA.
John P ShannonViral Immunity and Pathogenesis Unit, LCIM, NIAID, Bethesda, MD, USA.
Ian A MylesEpithelial Therapeutics Unit, LCIM, NIAID, Bethesda, MD, USA.
Peter OlbrichImmunopathogenesis Section, LCIM, NIAID, Bethesda, MD, USA.
Elise M N FerréFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, USA.
Monica SchmittFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, USA.
Daniel MartinGenomics and Computational Biology Core, NIDCR, Bethesda, MD, USA.
Genomics and Computational Biology Core16
Daniel L BarberT Lymphocyte Biology Section, Laboratory of Parasitic Diseases, NIAID, Bethesda, MD, USA.
Norma V SolisLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Luigi D NotarangeloImmune Deficiency Genetics Section, LCIM, NIAID, Bethesda, MD, USA.
David V SerrezeThe Jackson Laboratory, Bar Harbor, ME, USA.
Mitsuru MatsumotoDivision of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima, Japan.
Heather D HickmanEpithelial Therapeutics Unit, LCIM, NIAID, Bethesda, MD, USA.
Philip M MurphyMolecular Signaling Section, Laboratory of Molecular Immunology, NIAID, Bethesda, MD, USA.
Mark S AndersonDiabetes Center, University of California, San Francisco, CA, USA.
Jean K LimDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Steven M HollandImmunopathogenesis Section, LCIM, NIAID, Bethesda, MD, USA.
Scott G FillerLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Behdad AfzaliImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD, USA.
Yasmine BelkaidMetaorganism Immunity Section, Laboratory of Immune System Biology, NIAID, Bethesda, MD, USA.
Niki M MoutsopoulosOral Immunity and Inflammation Section, National Institute of Dental and Craniofacial Research (NIDCR), Bethesda, MD, USA.
Michail S LionakisFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, USA.
National Institute of Allergy and Infectious Diseases · USNational Institute of Dental and Craniofacial Research · USOrganogenesis (United States) · USNational Cancer Institute · USNational Institute of Diabetes and Digestive and Kidney Diseases · USNational Institutes of Health · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USJackson Laboratory · USUCLA Medical Center · USIcahn School of Medicine at Mount Sinai · USID Genomics (United States) · USJiangsu Institute of Parasitic Diseases · CNLaboratory of Molecular Genetics · PLUniversity of Maryland, Baltimore · US

Funding

Immunopathogenesis of Fungal InfectionsZIAAI001175 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LIONAKIS, MICHAIL · 2012 to 2025
$23.9M
C. albicans invasion and proliferation during oral infectionR01DE026600 · NIDCR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI FILLER, SCOTT G, MITCHELL, AARON P · 2017 to 2021
$3.0M
Endothelial invasion by yeast-phase CandidaR01AI124566 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI FILLER, SCOTT G, MITCHELL, AARON P · 2016 to 2020
$2.7M
Novel Candida albicans host receptors during infection and immune responseR00DE026856 · NIDCR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI SWIDERGALL, MARC · 2019 to 2021
$710k
Intramural NIH HHS ZIA AI001175NIAID NIH HHS K99 AI141622NIAID NIH HHS R01 AI124566NIDCR NIH HHS R00 DE026856NIDCR NIH HHS R01 DE026600
6 · The paper itself

Abstract

Puel and Casanova and Kisand

Indexed as

Immunity, MucosalMycosesAnimalsHumansMiceMucous Membrane

Identifiers

PMID34529475
PMCPMC10120387
OpenAlexW3201024801

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.