Evidence map›Paper›PMID 34529404›Full record

ArticleACS chemical neuroscience2021

Scaffold Hybridization Strategy Leads to the Discovery of Dopamine D

Alessandro Bonifazi, Amy H Newman, Thomas M Keck, Silvia Gervasoni, Giulio Vistoli, Fabio Del Bello, Gianfabio Giorgioni, Pegi Pavletić, Wilma Quaglia, Alessandro Piergentili

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. A Bioactive Benzyl Terpene fromMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Highly Potent and Selective Dopamine DJournal of medicinal chemistry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessandro BonifaziMedicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.ORCID 0000-0002-7306-0114
Amy H NewmanMedicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.ORCID 0000-0001-9065-4072
Thomas M KeckMedicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.ORCID 0000-0003-1845-9373
Silvia GervasoniDepartment of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, Milano 20133, Italy.
Giulio VistoliDepartment of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, Milano 20133, Italy.ORCID 0000-0002-3939-5172
Fabio Del BelloSchool of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, Camerino 62032, Italy.ORCID 0000-0001-6538-6029
Gianfabio GiorgioniSchool of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, Camerino 62032, Italy.ORCID 0000-0002-9576-6580
Pegi PavletićSchool of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, Camerino 62032, Italy.
Wilma QuagliaSchool of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, Camerino 62032, Italy.ORCID 0000-0002-7708-0200
Alessandro PiergentiliSchool of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S. Agostino 1, Camerino 62032, Italy.ORCID 0000-0001-6135-6826

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the search for novel bitopic compounds targeting the dopamine D

Indexed as

Antipsychotic AgentsCentral Nervous System DiseasesDopamineHumansLigandsAntipsychotic AgentsDopamineLigandsbitopic ligandscentral nervous system disordersdocking studiesdopamine D3 receptorsmultitarget compounds

Identifiers

PMID34529404
PMCPMC8498988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.