ArticleObesity (Silver Spring, Md.)2021
Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence.
Article in Obesity (Silver Spring, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- A systematic review of the relationship between portion size and indexes of adiposity in children.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- The Natural History of Prediabetes and Cardiovascular Disease in the Pediatric Population.Biomedicines · 2026Review
- Metabolic complications of obesity in children and adolescents.Clinical and experimental pediatrics · 2024Article
- Evaluation of the Prime Diet Quality Score from Early Childhood Through Mid-Adolescence.The Journal of nutrition · 2024Article
- Assessment of a consensus definition of obesity and metabolic health phenotypes in children at different pubertal stages.Scientific reports · 2022Article
- Impact of SARS-CoV2 on youth onset type 2 diabetes new diagnoses and severity.Journal of diabetes · 2022Article
- A Mini-Review of Pediatric Anthropometrics as Predictors of Future Insulin Resistance.Frontiers in endocrinology · 2022Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThis study examined the associations of central adiposity gain from midchildhood to early adolescence with cardiometabolic health markers in early adolescence.
methodsA total of 620 participants were studied in Project Viva. In midchildhood (mean age = 7.8 years) and early adolescence (12.9 years), waist circumference and dual-energy x-ray absorptiometry-measured visceral adipose tissue, subcutaneous abdominal adipose tissue, and trunk fat were obtained. Central adiposity gain was calculated as change per year between visits. Cardiometabolic health markers, including blood pressure, lipids, markers of insulin resistance, inflammation, and adipokines, were collected in early adolescence.
resultsGreater waist circumference gain was associated with higher log triglycerides (β 0.07 mg/dL; 95% CI: 0.02-0.13), log alanine aminotransferase (0.07 U/L; 95% CI: 0.03-0.12), log high-sensitivity C-reactive protein (0.43 mg/L; 95% CI: 0.28-0.58), and other cardiometabolic markers in early adolescence. Directly measured central adiposity gains were associated with higher systolic blood pressure z score in early adolescence (visceral adipose tissue [0.13 SD units; 95% CI: 0.04-0.23], subcutaneous abdominal adipose tissue [0.18 SD units; 95% CI: 0.04-0.31], and trunk fat [0.21 SD units; 95% CI: 0.06-0.36]). These associations were independent of baseline and change in total adiposity from midchildhood to early adolescence.
conclusionsMonitoring central adiposity gain may enable identification and intervention in children vulnerable to developing cardiometabolic health risks.
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Registered trials
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