ArticleJournal of applied clinical medical physics2021
Initial analysis of the dosimetric benefit and clinical resource cost of CBCT-based online adaptive radiotherapy for patients with cancers of the cervix or rectum.
Article in Journal of applied clinical medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Prospective multi-institutional study of library-based adaptive radiotherapy for cervical cancer: Evaluation of plan-of-the-day selection and population analysis.Journal of applied clinical medical physics · 2025Trial
- Improving deep learning organ segmentation accuracy in cone-beam CT-guided radiotherapy using a robust scatter suppression method.Physics and imaging in radiation oncology · 2026Article
- Article
- Best Practice: CT-guided Adaptive Radiotherapy Reference Planning on the Ethos Platform.Journal of applied clinical medical physics · 2026Review
- Article
- Assessing Dosimetric Benefits of Cone Beam Computed Tomography-Guided Online Adaptive Radiation Treatment Frequencies for Lung Cancer.Advances in radiation oncology · 2025Article
- Evaluating CBCT-Guided Adaptive Radiotherapy for Pancreatic Cancer Using Synthetic CBCT Data.Current oncology (Toronto, Ont.) · 2025Article
- Evaluating the Implementation of fan-beam CT-guided online adaptive re-planning in definitive cervical cancer radiotherapy.Frontiers in oncology · 2025Article
- Proof of concept of fully automated adaptive workflow for head and neck radiotherapy treatments with a conventional linear accelerator.Frontiers in oncology · 2025Article
- Adaptive Approach to Treating Cervical Cancer in a Patient With Dramatic Uterine Movement.Cureus · 2024Article
- Split-Course Adaptive Radioimmunotherapy for Oligometastatic Non-Small Cell Lung Cancer (SiCARIO): A Case Report.Cureus · 2024Article
- Using Scorecards to Tune Ethos Directive Templates: An Adaptive Radiation Therapy Individualized Approach-Cervix Dosimetric Planning Study.Advances in radiation oncology · 2024Article
- Unlocking the adaptive advantage: correlation and machine learning classification to identify optimal online adaptive stereotactic partial breast candidates.Physics in medicine and biology · 2024Article
- The clinical practice and dosimetric outcome of the manual adaptive planning during definitive radiotherapy for cervical cancer.Journal of cancer research and clinical oncology · 2024Article
- Adaptive Radiotherapy: Next-Generation Radiotherapy.Cancers · 2024Review
- Enhancing Safety in AI-Driven Cone Beam CT-based Online Adaptive Radiation Therapy: Development and Implementation of an Interdisciplinary Workflow.Advances in radiation oncology · 2024Article
- Empirical analysis of a plan-of-the-day strategy to approximate daily online reoptimization for prostate CBCT-guided adaptive radiotherapy.Journal of applied clinical medical physics · 2024Article
- First implementation and results of online adaptive radiotherapy for cervical cancer based on CT-Linac combination.Frontiers in oncology · 2024Article
- Predicting cervical cancer target motion using a multivariate regression model to enable patient selection for adaptive external beam radiotherapy.Physics and imaging in radiation oncology · 2024Article
- A head and neck treatment planning strategy for a CBCT-guided ring-gantry online adaptive radiotherapy system.Journal of applied clinical medical physics · 2023Article
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5 authors.
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Abstract
purposeThis provides a benchmark of dosimetric benefit and clinical cost of cone-beam CT-based online adaptive radiotherapy (ART) technology for cervical and rectal cancer patients.
methodsAn emulator of a CBCT-based online ART system was used to simulate more than 300 treatments for 13 cervical and 15 rectal cancer patients. CBCT images were used to generate adaptive replans. To measure clinical resource cost, the six phases of the workflow were timed. To evaluate the dosimetric benefit, changes in dosimetric values were assessed. These included minimum dose (Dmin) and volume receiving 95% of prescription (V95%) for the planning target volume (PTV) and the clinical target volume (CTV), and maximum 2 cc's (D2cc) of the bladder, bowel, rectum, and sigmoid colon.
resultsThe average duration of the workflow was 24.4 and 9.2 min for cervical and rectal cancer patients, respectively. A large proportion of time was dedicated to editing target contours (13.1 and 2.7 min, respectively). For cervical cancer patients, the replan changed the Dmin to the PTVs and CTVs for each fraction 0.25 and 0.25 Gy, respectively. The replan changed the V95% by 9.2 and 7.9%. The D2cc to the bladder, bowel, rectum, and sigmoid colon for each fraction changed -0.02, -0.08, -0.07, and -0.04 Gy, respectively. For rectal cancer patients, the replan changed the Dmin to the PTVs and CTVs for each fraction of 0.20 and 0.24 Gy, respectively. The replan changed the V95% by 4.1 and 1.5%. The D2cc to the bladder and bowel for each fraction changed 0.02 and -0.02 Gy, respectively.
conclusionsDosimetric benefits can be achieved with CBCT-based online ART that is amenable to conventional appointment slots. The clinical significance of these benefits remains to be determined. Managing contours was the primary factor affecting the total duration and is imperative for safe and effective adaptive radiotherapy.
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