Evidence map›Paper›PMID 34529321›Full record

ReviewProtein science : a publication of the Protein Society2022

The evolution of the antimicrobial peptide database over 18 years: Milestones and new features.

Guangshun Wang, C Michael Zietz, Ashok Mudgapalli, Shuona Wang, Zhe Wang

Abstract readHistorical ArticleReview
In one paragraph

Review in Protein science : a publication of the Protein Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

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  20. The Effect of Antimicrobial Peptide (PA-13) onAntibiotics (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guangshun WangDepartment of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0002-4841-7927
C Michael ZietzResearch Information Technology Office, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Ashok MudgapalliResearch Information Technology Office, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Shuona WangDepartment of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, Nebraska, USA.
Zhe WangDepartment of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, Nebraska, USA.

Funding

Novel Janus-type Antimicrobial Dressings for the Treatment of Biofilms in Chronic WoundsR01GM138552 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, GUANGSHUN, XIE, JINGWEI · 2020 to 2023
$2.2M
Database designed novel anti-MRSA peptidesR01AI105147 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, GUANGSHUN · 2015 to 2019
$1.9M
T-cell-Alveolar Macrophage Crosstalk during Influenza and Streptococcus Pneumoniae Co-infectionR56AI137161 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, GUANGSHUN · 2019 to 2019
$419k
Surface antimicrobial coating to prevent bacterial biofilmsR03AI128230 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, GUANGSHUN · 2017 to 2018
$151k
NIAID NIH HHS R01 AI105147NIAID NIH HHS R03 AI128230NIAID NIH HHS R56 AI137161NIGMS NIH HHS R01 GM138552
6 · The paper itself

Abstract

The antimicrobial peptide database (APD) has served the antimicrobial peptide field for 18 years. Because it is widely used in research and education, this article documents database milestones and key events that have transformed it into the current form. A comparison is made for the APD peptide statistics between 2010 and 2020, validating the major database findings to date. We also describe new additions ranging from peptide entries to search functions. Of note, the APD also contains antimicrobial peptides from host microbiota, which are important in shaping immune systems and could be linked to a variety of human diseases. Finally, the database has been re-programmed to the web branding and latest security compliance of the University of Nebraska Medical Center. The reprogrammed APD can be accessed at https://aps.unmc.edu.

Indexed as

Antimicrobial PeptidesComputational BiologyDatabases, ProteinHistory, 21st CenturyAntimicrobial Peptidesantimicrobial peptidesAPDdatabasemicrobiotapeptide designpeptide prediction

Identifiers

PMID34529321
PMCPMC8740828

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.