Evidence map›Paper›PMID 34529278›Full record

ArticleThe Prostate2021

Prostate tumors of native men from West Africa show biologically distinct pathways-A comparative genomic study.

Kosj Yamoah, Francis A Asamoah, Afua O D Abrahams, Shivanshu Awasthi, James E Mensah, Jasreman Dhillon, Brandon A Mahal, Serigne Magueye Gueye, Mohamed Jalloh, Sahar J Farahani and 3 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Prostate, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 3 countries.

Kosj YamoahDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.ORCID 0000-0001-9055-3538
Francis A AsamoahNational Center for Radiotherapy, Oncology and Nuclear Medicine, Korle Bu Teaching Hospital Accra, Accra, Ghana.
Afua O D AbrahamsDepartment of Pathology, University of Ghana Medical School, Korle bu Teaching Hospital, Accra, Ghana.
Shivanshu AwasthiDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.ORCID 0000-0003-4175-3212
James E MensahDepartment of Surgery, University of Ghana Medical School, Korle bu Teaching Hospital, Accra, Ghana.
Jasreman DhillonDepartment of Pathology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.
Brandon A MahalDepartment of Radiation Oncology, University of Miami, Miami, Florida, USA.
Serigne Magueye GueyeHospital General Idrissa Pouye, Dakar, Senegal.
Mohamed JallohHospital General Idrissa Pouye, Dakar, Senegal.
Sahar J FarahaniDepartment of Pathology, Stony Brook University, New York city, New York, USA.
Priti LalDepartment of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Timothy R RebbeckDana Farber Cancer Institute and Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Joel YarneyNational Center for Radiotherapy, Oncology and Nuclear Medicine, Korle Bu Teaching Hospital Accra, Accra, Ghana.
Moffitt Cancer Center · USHôpital Principal de Dakar · SNKorle Bu Teaching Hospital · GHUniversity of Ghana · GHDana-Farber Cancer Institute · USStony Brook University · USUniversity of Miami · USUniversity of Pennsylvania · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Precision Interception of Aggressive Prostate Cancer in African American MenP20CA233255 · NCI · DANA-FARBER CANCER INST · PI REBBECK, TIMOTHY R · 2018 to 2020
$3.2M
NCI NIH HHS P20 CA233255NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

backgroundNative African men (NAM) experience a disproportionate burden of prostate cancer (PCa) and have higher mortality rates compared to European American men (EAM). While socioeconomic status has been implicated as a driver of this disparity, little is known about the genomic mechanisms and distinct biological pathways that are associated with PCa of native men of African origin.

methodsTo understand biological factors that contribute to this disparity we utilized a total of 406 multi-institutional localized PCa samples, collected by Men of African Descent and Carcinoma of the Prostate biospecimen network and Moffitt Cancer Center/University of Pennsylvania Health science system. We performed comparative genomics and immunohistochemistry to identify the biomarkers that are highly enriched in NAM from west Africa and compared them with African American Men (AAM) and EAM. Quantified messenger RNA expression and Median H scores based on immune reactivity of staining cells, were compared using Mann Whitney test. For gene expression analysis, p values were further adjusted for multiple comparisons using false discovery rates.

resultsImmunohistochemical analysis on selected biomarkers showed a consistent association between ETS related gene (ERG) status and race with 83% of NAM exhibiting tumors that lacked TMPRSS2-ERG translocation (ERG

conclusionsProstate tumors in NAM are genomically distinct and are characterized by the dysregulation of several biomarkers. Furthermore, these tumors are also highly enriched for the major proinflammatory pathways. These distinct biological features may have implications for diagnosis and response to targeted therapy among Black men, globally.

Indexed as

CarcinomaProstatic NeoplasmsBiological Specimen BanksBlack or African AmericanBlack PeopleEther-A-Go-Go Potassium ChannelsGene Expression ProfilingGenetic TestingGenomicsGhanaHumansImmunohistochemistryMaleMiddle AgedSenegalSerine EndopeptidasesEther-A-Go-Go Potassium ChannelsKCNH6 protein, humanSerine EndopeptidasesTMPRSS2 protein, humannative African menprostate cancerprostate genomicsrace disparities

Identifiers

PMID34529278
PMCPMC8563425
OpenAlexW3200873116

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.