ArticleIrish journal of medical science2022
Evaluation of hematological parameters and inflammatory markers in children with COVID-19.
Article in Irish journal of medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Inflammatory Markers Stratify Surgical Outcomes in Pediatric Airway Reconstruction.The Laryngoscope · 2026Article
- Remdesivir safety and clinical outcomes in pediatric COVID-19: a retrospective study.BMC infectious diseases · 2025Article
- The role of NOS3-rs1799983 and NOS3- rs2070744 SNP in occurrence of avascular necrosis as a post COVID-19 complication.BMC medical genomics · 2024Article
- Vitamin D Levels in COVID-19 and NonCOVID-19 Pediatric Patients and Its Relationship with Clinical and Laboratory Characteristics.Biomedicines · 2024Article
- Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones-a comparative study.Frontiers in pediatrics · 2024Article
- COVID-19 frequency and clinical course in children with asthma.World journal of virology · 2023Article
- Distinct Immune Phenotypes and Cytokine Profiles in Children with Differing Severity of COVID-19.The Pediatric infectious disease journal · 2022Article
- Biomarker Changes in Pediatric Patients With COVID-19: A Retrospective Study from a Single Center Database.In vivo (Athens, Greece)Article
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5 authors.
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Abstract
backgroundThe aim of this study was to evaluate hematological parameters in children with COVID-19 and determine the effects of inflammatory biomarkers on the assessment of hospitalization.
methodsThis retrospective single-center study was performed on 633 children with COVID-19 between March 2020 and January 2021. The study population was separated into two groups: inpatients (n = 83) and outpatients (n = 550). Univariate and multivariate logistic regression was applied to identify risk factors for hospitalization.
resultsLymphopenia (n = 228, 36%) was found mainly to be a hematological abnormality in all cases. Compared with outpatients, inpatients had significantly higher white blood cell (WBC) (p = 0.005), lymphocyte (p < 0.001), and platelet counts (p = 0.036), and significantly higher red cell distribution width (p = 0.001), C-reactive protein (CRP) (p = 0.003), procalcitonin (p = 0.001), D-dimer (p < 0.001), and lymphocyte to monocyte ratio values (p = 0.004). On the other hand, they had significantly lower values of hemoglobin (p < 0.001), neutrophil to lymphocyte ratio (p = 0.024), platelet lymphocyte ratio (p = 0.001), derivated neutrophil to lymphocyte ratio (p = 0.037), and mean platelet volume to lymphocyte ratio (p < 0.001). ROC analysis showed that WBC, CRP, and procalcitonin cutoff values were the best discriminated between inpatients and outpatients. The results for the areas under the curve of WBC, CRP, and procalcitonin used to assess patients' hospitalization were 0.595 (95% CI 0.519-0.670, p = 0.005), 0.599 (95% CI 0.527-0.672, p = 0.003), and 0.599 (95% CI 0.525-0.673, p = 0.004), respectively.
conclusionWe suggest that high WBC and procalcitonin levels can be used as independent predictors of hospitalization in children with COVID-19.
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