Evidence map›Paper›PMID 34529189›Full record

ArticleJournal of natural medicines2022

Anti-trypanosomal screening of Salvadoran flora.

Ulises G Castillo, Ayato Komatsu, Morena L Martínez, Jenny Menjívar, Marvin J Núñez, Yoshinori Uekusa, Yuji Narukawa, Fumiyuki Kiuchi, Junko Nakajima-Shimada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural medicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ulises G CastilloLaboratorio de Investigación en Productos Naturales, Facultad de Química y Farmacia, Universidad de El Salvador, Final Av. de Mártires y Héroes del 30 de Julio, San Salvador, 1101, El Salvador.
Ayato KomatsuFaculty of Pharmacy, Division of Natural Medicines, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Tokyo, 105-8512, Japan.
Morena L MartínezLaboratorio de Investigación en Productos Naturales, Facultad de Química y Farmacia, Universidad de El Salvador, Final Av. de Mártires y Héroes del 30 de Julio, San Salvador, 1101, El Salvador.
Jenny MenjívarMinisterio de Cultura, Museo de Historia Natural de El Salvador, San Salvador, 1101, El Salvador.
Marvin J NúñezLaboratorio de Investigación en Productos Naturales, Facultad de Química y Farmacia, Universidad de El Salvador, Final Av. de Mártires y Héroes del 30 de Julio, San Salvador, 1101, El Salvador.
Yoshinori UekusaFaculty of Pharmacy, Division of Natural Medicines, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Tokyo, 105-8512, Japan.
Yuji NarukawaFaculty of Pharmacy, Division of Natural Medicines, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Tokyo, 105-8512, Japan.
Fumiyuki KiuchiFaculty of Pharmacy, Division of Natural Medicines, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, Tokyo, 105-8512, Japan. kiuchi-fm84@keio.jp.ORCID http://orcid.org/0000-0002-9338-5047
Junko Nakajima-ShimadaGraduate School of Health Sciences, Gunma University, 3-39-22 Showamachi, Maebashi, Gunma, 371-8514, Japan.

Funding

japan agency for medicinal research and development JP: 19jm0110016h0303japan agency for medicinal research and development JP: 20jm20jm0110016h0004
6 · The paper itself

Abstract

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and in Central America, it is considered one of the four most infectious diseases. This study aimed to screen the anti-trypanosomal activity of plant species from Salvadoran flora. Plants were selected through literature search for plants ethnobotanically used for antiparasitic and Chagas disease symptomatology, and reported in Museo de Historia Natural de El Salvador (MUHNES) database. T. cruzi was incubated for 72 h with 2 different concentrations of methanolic extracts of 38 species, among which four species, Piper jacquemontianum, Piper lacunosum, Trichilia havanensis, and Peperomia pseudopereskiifolia, showed the activity (≤ 52.0% viability) at 100 µg/mL. Separation of the methanolic extract of aerial parts from Piper jacquemontianum afforded a new flavanone (4) and four known compounds, 2,2-dimethyl-6-carboxymethoxychroman-4-one (1), 2,2-dimethyl-6-carboxychroman-4-one (2), cardamomin (3), and pinocembrin (5), among which cardamomin exhibited the highest anti-trypanosomal activity (IC

Indexed as

Trypanocidal AgentsTrypanosoma cruziChagas DiseaseHumansMeliaceaePeperomiaPiperPlant ExtractsPlant ExtractsTrypanocidal AgentsChagas diseaseFlavonoidsPiper jacquemontianumSalvadoran floraTrypanosoma cruzi

Identifiers

PMID34529189
PMCPMC8732892

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.