ArticleEuropean journal of applied physiology2021
Caffeine, genetic variation and anaerobic performance in male athletes: a randomized controlled trial.
Article in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02109783 (Genetic Modifiers of Caffeine Intake and Athletic Performance), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Modifiers of Caffeine Intake and Athletic Performance
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Does ergogenic effect of caffeine supplementation depend on CYP1A2 genotypes? A systematic review with meta-analysis.Journal of sport and health science · 2024Pooled it
- The Effect of CYP1A2 Gene Polymorphisms on Caffeine Pharmacokinetics and Exercise Performance in Male Recreational Athletes.European journal of sport science · 2026Trial
- Dose and timing effects of caffeine on subsequent sleep: a randomized clinical crossover trial.Sleep · 2025Trial
- Influence of the CYP1A2 c.European journal of nutrition · 2024Trial
- The effect of caffeine on exercise performance is not influenced by ADORA2A genotypes, alone or pooled with CYP1A2 genotypes, in adolescent athletes.European journal of nutrition · 2023Trial
- Effect of caffeine on muscle oxygen saturation during short-term all-out exercise: a double-blind randomized crossover study.European journal of nutrition · 2022Trial
- Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review.Current nutrition reports · 2025Review
- Positive and Negative Expectations Associated with Coffee and Energy Drinks: Implications for Placebo-Nocebo Research in Sports.Nutrients · 2025Article
- Low-Dose Caffeine Supplementation Is a Valuable Strategy for Increasing Time to Exhaustion, Explosive Power, and Reducing Muscle Soreness in Professional Male Kickboxers.Current developments in nutrition · 2025Article
- Exploring the relationship between caffeine metabolism-related CYP1A2 rs762551 polymorphism and team sport athlete status and training adaptations.Molecular biology reports · 2024Article
- Genes and Athletic Performance: The 2023 Update.Genes · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe effect of caffeine on anaerobic performance is unclear and may differ depending on an individual's genetics. The goal of this study was to determine whether caffeine influences anaerobic performance in a 30 s Wingate test, and if 14 single nucleotide polymorphisms (SNPs) in nine genes, associated with caffeine metabolism or response, modify caffeine's effects.
methodsCompetitive male athletes (N = 100; 25 ± 4 years) completed the Wingate under three conditions: 0, 2, or 4 mg of caffeine per kg of body mass (mg kg
resultsThere was no main effect of caffeine on Wingate outcomes. One significant caffeine-gene interaction was observed for CYP1A2 (rs762551, p = 0.004) on average power. However, post hoc analysis showed no difference in caffeine's effects within CYP1A2 genotypes for average power performance. No significant caffeine-gene interactions were observed for the remaining SNPs on peak power, average power and fatigue index.
conclusionCaffeine had no effect on anaerobic performance and variations in several genes did not modify any effects of caffeine.
trial registrationThis study was registered with clinicaltrials.gov (NCT02109783).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.