ArticleJournal of biomechanical engineering2022
Models of Shear-Induced Platelet Activation and Numerical Implementation With Computational Fluid Dynamics Approaches.
Article in Journal of biomechanical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Computational and Experimental Assessment of Shear-Induced Blood Trauma by HeartMate II, HeartMate 3, and BrioVAD.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Platelet gene signatures detecting pulmonary artery stenosis in patients with pulmonary hypertension.Orphanet journal of rare diseases · 2026Article
- Platelet Adhesion and Aggregation Dynamics over Collagen- and VWF-coated Surfaces: Insights from Dissipative Particle Dynamics Simulations and Microfluidic Experiments.Bulletin of mathematical biology · 2026Article
- Blood Mechanical Intelligence: From Force Sensing to Precision Mechanomedicine.Research (Washington, D.C.) · 2026Review
- Computational Fluid Dynamic Analysis of Fluid Motion and Volumetric Gas-Liquid Mass Transfer in Agitated Platelet Concentrate Storage.Biotechnology journal · 2026Article
- A 2D computational model of chemically- and mechanically-induced platelet plug formation.Biomechanics and modeling in mechanobiology · 2025Article
- A Biophysics-Based Mathematical Model of Shear-Induced Platelet Activation and Receptor Shedding: Re-Examining Previous Experimental Data.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2025Article
- Targeting platelet-tumor cell interactions: a novel approach to cancer therapy.Medical oncology (Northwood, London, England) · 2025Review
- Fluid Dynamic and in Vitro Blood Study to Understand Catheter-Related Thrombosis.Cardiovascular engineering and technology · 2025Article
- Investigation of the role of von Willebrand factor in shear-induced platelet activation and functional alteration under high non-physiological shear stress.Artificial organs · 2024Article
- Computational fluid dynamics-based design and in vitro characterization of a novel pediatric pump-lung.Artificial organs · 2024Article
- Decoding thrombosis through code: a review of computational models.Journal of thrombosis and haemostasis : JTH · 2024Review
- A prestressed intracellular biomechanical model for the platelet to capture the disc-to-sphere morphological change from resting to activated state.International journal of computational methods · 2022Article
- On the Three-dimensionality of Flow in the Neo-sinus and its Implications for Subclinical Leaflet Thrombosis.Interactive cardiovascular and thoracic surgery · 2022Article
- Computational fluid dynamics analysis and experimental hemolytic performance of three clinical centrifugal blood pumps: Revolution, Rotaflow and CentriMag.Medicine in novel technology and devices · 2022Article
- Development of an Ambulatory Extracorporeal Membrane Oxygenation System: From Concept to Clinical Use.Applications in engineering science · 2022Article
- Computational Analysis of Flow Structures in Turbulent Ventricular Blood Flow Associated With Mitral Valve Intervention.Frontiers in physiology · 2022Article
- Patient specific approach to analysis of shear-induced platelet activation in haemodialysis arteriovenous fistula.PloS one · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Shear-induced platelet activation is one of the critical outcomes when blood is exposed to elevated shear stress. Excessively activated platelets in the circulation can lead to thrombus formation and platelet consumption, resulting in serious adverse events such as thromboembolism and bleeding. While experimental observations reveal that it is related to the shear stress level and exposure time, the underlying mechanism of shear-induced platelet activation is not fully understood. Various models have been proposed to relate shear stress levels to platelet activation, yet most are modified from the empirically calibrated power-law model. Newly developed multiscale platelet models are tested as a promising approach to capture a single platelet's dynamic shape during activation, but it would be computationally expensive to employ it for a large-scale analysis. This paper summarizes the current numerical models used to study the shear-induced platelet activation and their computational applications in the risk assessment of a particular flow pattern and clot formation prediction.
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