Evidence map›Paper›PMID 34528945›Full record

ArticleChemical communications (Cambridge, England)2021

Synthesis and delivery of a stable phosphorylated ubiquitin probe to study ubiquitin conjugation in mitophagy.

Guy Mann, Gandhesiri Satish, Prasad Sulkshane, Shaswati Mandal, Michael H Glickman, Ashraf Brik

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Cytosolic Delivery of Functional Ubiquitin.Journal of peptide science : an official publication of the European Peptide Society · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Probing the cell delivery of synthetic diubiquitin chains.Chemical communications (Cambridge, England) · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. The chemical biology of ubiquitin.Biochimica et biophysica acta. General subjects · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guy MannSchulich Faculty of Chemistry, Technion-Israel Institute of Technology Haifa, 3200008, Israel. abrik@technion.ac.il.ORCID http://orcid.org/0000-0003-3356-6302
Gandhesiri SatishSchulich Faculty of Chemistry, Technion-Israel Institute of Technology Haifa, 3200008, Israel. abrik@technion.ac.il.
Prasad SulkshaneFaculty of Biology, Technion-Israel Institute of Technology Haifa, 3200008, Israel. glickman@tx.technion.ac.il.
Shaswati MandalSchulich Faculty of Chemistry, Technion-Israel Institute of Technology Haifa, 3200008, Israel. abrik@technion.ac.il.
Michael H GlickmanFaculty of Biology, Technion-Israel Institute of Technology Haifa, 3200008, Israel. glickman@tx.technion.ac.il.
Ashraf BrikSchulich Faculty of Chemistry, Technion-Israel Institute of Technology Haifa, 3200008, Israel. abrik@technion.ac.il.ORCID http://orcid.org/0000-0001-8745-2250

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein post-translational modifications are involved in essentially all aspects of cellular signaling. Their dynamic nature and the difficulties in installing them using enzymatic approaches limits their direct study in human cells. Reported herein is the first synthesis, delivery and cellular study of a stable phosphoubiquitin probe. Our results compare Parkin's substrate preference during mitophagy

Indexed as

Cell Line, TumorHumansMolecular ProbesMolecular StructurePhosphorylationProtein Processing, Post-TranslationalUbiquitinMolecular ProbesUbiquitin

Identifiers

PMID34528945
PMCPMC8445162

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.