ArticleThe Journal of infectious diseases2021
Pathogens Associated With Linear Growth Faltering in Children With Diarrhea and Impact of Antibiotic Treatment: The Global Enteric Multicenter Study.
Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.
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Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Anthropometric and neurocognitive consequences of Campylobacter, enterotoxigenic Escherichia coli, and norovirus: A systematic review.PLoS neglected tropical diseases · 2025Pooled it
- Consequences of Shigella infection in young children: a systematic review.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023Pooled it
- Personalized azithromycin treatment rules for children with watery diarrhea using machine learning.Nature communications · 2025Trial
- Minimal Impact on the Resistome of Children in Botswana After Azithromycin Treatment for Acute Severe Diarrheal Disease.The Journal of infectious diseases · 2024Trial
- Azithromycin for Bacterial Watery Diarrhea: A Reanalysis of the AntiBiotics for Children With Severe Diarrhea (ABCD) Trial Incorporating Molecular Diagnostics.The Journal of infectious diseases · 2024Trial
- Optimising the management of childhood acute diarrhoeal disease using a rapid test-and- treat strategy and/orBMJ global health · 2022Trial
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- The consequences ofEClinicalMedicine · 2026Article
- Performance of fecal inflammatory biomarkers to identify watery shigellosis: Findings from the Enterics for Global Health (EFGH) Shigella surveillance study.PLoS neglected tropical diseases · 2026Article
- EatA mediated degradation of intestinal mucus is species-specific and driven by MUC2 structural features.Nature communications · 2025Article
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- An Asset for Food Safety: The Knowledge Behind the Physiological Alterations Induced by ETEC Enterotoxins.Foods (Basel, Switzerland) · 2025Review
- Shigellosis.Lancet (London, England) · 2025Review
- ETEC biofilms are regulated by magnesium and lactate bioavailability.Infection and immunity · 2025Article
- Clinico-Epidemiological Characteristics of Symptomatic and Asymptomatic Enterotoxigenic and Enteropathogenic Escherichia Coli Diarrhea and Impact on Child Growth.The American journal of tropical medicine and hygiene · 2025Article
- Transitory impact of subclinical Shigella infections on biomarkers of environmental enteropathy in children under 2 years.PLoS neglected tropical diseases · 2025Article
- Article
- Impact of water, sanitation, and hygiene indicators on enteric viral pathogens among under-5 children in low resource settings.The Science of the total environment · 2025Article
- Microphysiological gut-on-chip enables extendedFrontiers in cellular and infection microbiology · 2025Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
41 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between childhood diarrheal disease and linear growth faltering in developing countries is well described. However, the impact attributed to specific pathogens has not been elucidated, nor has the impact of recommended antibiotic treatment.
methodsThe Global Enteric Multicenter Study enrolled children with moderate to severe diarrhea (MSD) seeking healthcare at 7 sites in sub-Saharan Africa and South Asia. At enrollment, we collected stool samples to identify enteropathogens. Length/height was measured at enrollment and follow-up, approximately 60 days later, to calculate change in height-for-age z scores (ΔHAZ). The association of pathogens with ΔHAZ was tested using linear mixed effects regression models.
resultsAmong 8077 MSD cases analyzed, the proportion with stunting (HAZ below -1) increased from 59% at enrollment to 65% at follow-up (P < .0001). Pathogens significantly associated with linear growth decline included Cryptosporidium (P < .001), typical enteropathogenic Escherichia coli (P = .01), and untreated Shigella (P = .009) among infants (aged 0-11 months) and enterotoxigenic E. coli encoding heat-stable toxin (P < .001) and Cryptosporidium (P = .03) among toddlers (aged 12-23 months). Shigella-infected toddlers given antibiotics had improved linear growth (P = .02).
conclusionsLinear growth faltering among children aged 0-23 months with MSD is associated with specific pathogens and can be mitigated with targeted treatment strategies, as demonstrated for Shigella.
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