Evidence map›Paper›PMID 34528458›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021

Predicting critical closing pressure in children with obstructive sleep apnea using fluid-structure interaction.

Goutham Mylavarapu, Ephraim Gutmark, Sally Shott, Robert Fleck, Mohamed Mahmoud, Keith McConnell, Rhonda Szczesniak, Md Monir Hossain, Guixia Huang, Dawit G Tadesse and 3 more

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Goutham MylavarapuDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0002-6053-3170
Ephraim GutmarkDepartment of Aerospace Engineering and Engineering Mechanics, University of Cincinnati, Cincinnati, Ohio.
Sally ShottDivision of Otolaryngology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Robert FleckDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Mohamed MahmoudDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Keith McConnellDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Rhonda SzczesniakDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Md Monir HossainDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Guixia HuangDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Dawit G TadesseDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Christine L SchulerDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Sid KhoslaDepartment of Otolaryngology, University of Cincinnati, Cincinnati, Ohio.
Raouf AminDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0002-4942-6024

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Dynamic Computational Modeling of Obstructive Sleep Apnea in Down SyndromeR01HL105206 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI AMIN, RAOUF S., FLECK, ROBERT JOSEPH · 2010 to 2013
$3.7M
NCATS NIH HHS 1UL1TR001425-01NCATS NIH HHS UL1 TR001425NHLBI NIH HHS R01 HL105206NIH HHS 1R01HL105206-01
6 · The paper itself

Abstract

Surgical treatment of obstructive sleep apnea (OSA) in children requires knowledge of upper airway dynamics, including the closing pressure (Pcrit), a measure of airway collapsibility. We applied a flow-structure interaction (FSI) computational model to estimate Pcrit in patient-specific upper airway models obtained from magnetic resonance imaging (MRI) scans. We sought to examine the agreement between measured and estimated Pcrit from FSI models in children with Down syndrome. We hypothesized that the estimated Pcrit would accurately reflect measured Pcrit during sleep and therefore reflect the severity of OSA as measured by the obstructive apnea-hypopnea index (AHI). All participants (

Indexed as

PharynxSleep Apnea, ObstructiveChildHumansMagnetic Resonance ImagingPolysomnographySleepcomputational modelingDown syndromefluid-structure interactionsobstructive sleep apneaupper airway

Identifiers

PMID34528458
PMCPMC8616603

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.