ArticleEuropean journal of neurology2022
Increased delta power as a scalp marker of epileptic activity: a simultaneous scalp and intracranial electroencephalography study.
Article in European journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Translatable electrophysiological and behavioral abnormalities in a humanized model of SYNGAP1-disorder.Molecular psychiatry · 2026Article
- Assessing Strengths and Limitations of Magnetoencephalography Source Imaging With Intracerebral EEG.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Low-intensity transcranial ultrasound stimulation suppresses abnormal neural oscillations in the motor cortex by stimulating STN in α-synucleinActa neuropathologica communications · 2026Article
- Microelectrode array scaled for human hippocampal slices.Epilepsia open · 2026Article
- Article
- A spectral- topological network signature of drug-resistant epilepsy: a phase 1-2 study on resting-state EEG-based diagnostic biomarkers of drug resistance.NeuroImage. Clinical · 2026Observational
- Electroencephalographic Biomarkers in Tinnitus: A Narrative Review of Current Approaches and Clinical Perspectives.Brain sciences · 2025Review
- ICU-EEG Pattern Detection by a Convolutional Neural Network.Annals of clinical and translational neurology · 2025Article
- The Role of Electroencephalography in Predicting Post-Stroke Seizures and an Updated Prognostic Model (SeLECT-EEG).Annals of neurology · 2025Article
- Optimizing electrode configurations for EEG mild cognitive impairment detection.Scientific reports · 2025Article
- EEG focal delta slowing in focal epilepsy - A didactic review.Clinical neurophysiology practice · 2025Review
- Deep learning models using intracranial and scalp EEG for predicting sedation level during emergence from anaesthesia.BJA open · 2024Article
- Simultaneous invasive and non-invasive recordings in humans: A novel Rosetta stone for deciphering brain activity.Journal of neuroscience methods · 2024Review
- Cenobamate modulates EEG cortical activity and connectivity in individuals with drug-resistant epilepsy: a pharmaco-EEG study.Frontiers in neurology · 2024Article
- Utilizing GO/PEDOT:PSS/PtNPs-enhanced high-stability microelectrode arrays for investigating epilepsy-induced striatal electrophysiology alterations.Frontiers in bioengineering and biotechnology · 2024Article
- Treating Hyperexcitability in Human Cerebral Organoids Resulting from Oxygen-Glucose Deprivation.Cells · 2023Article
- A comprehensive wireless neurological and cardiopulmonary monitoring platform for pediatrics.PLOS digital health · 2023Article
- Sevoflurane-induced high-frequency oscillations, effective connectivity and intraoperative classification of epileptic brain areas.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- MEG Node Degree for Focus Localization: Comparison with Invasive EEG.Biomedicines · 2023Article
- MiR-324-5p inhibition after intrahippocampal kainic acid-inducedFrontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe purpose was to evaluate whether intracranial interictal epileptiform discharges (IEDs) that are not visible on the scalp are associated with changes in the frequency spectrum on scalp electroencephalograms (EEGs).
methodsSimultaneous scalp high-density EEG and intracranial EEG recordings were recorded in nine patients undergoing pre-surgical invasive recordings for pharmaco-resistant temporal lobe epilepsy. Epochs with hippocampal IED visible on intracranial EEG (ic-IED) but not on scalp EEG were selected, as well as control epochs without ic-IED. Welch's power spectral density was computed for each scalp electrode and for each subject; the power spectral density was further averaged across the canonical frequency bands and compared between the two conditions with and without ic-IED. For each patient the peak frequency in the delta band (the significantly strongest frequency band in all patients) was determined during periods of ic-IED. The five electrodes showing strongest power at the peak frequency were also determined.
resultsIt was found that intracranial IEDs are associated with an increase in delta power on scalp EEGs, in particular at a frequency ≥1.4 Hz. Electrodes showing slow frequency power changes associated with IEDs were consistent with the hemispheric lateralization of IEDs. Electrodes with maximum power of slow activity were not limited to temporal regions but also involved frontal (bilateral or unilateral) regions.
conclusionsIn patients with a clinical picture suggestive of temporal lobe epilepsy, the presence of delta slowing ≥1.4 Hz in anterior temporal regions can represent a scalp marker of hippocampal IEDs. To our best knowledge this is the first study that demonstrates the co-occurrence of ic-IED and increased delta power.
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