Evidence map›Paper›PMID 34528311›Full record

ArticleJournal of neuroendocrinology2021

Activation of nucleus accumbens μ-opioid receptors enhances the response to a glycaemic challenge.

Laura L Koekkoek, Tess Kool, Leslie Eggels, Luna L van der Gun, Khalid Lamuadni, Margo Slomp, Charlene Diepenbroek, Mireillle J Serlie, Andries Kalsbeek, Susanne E la Fleur

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Brain-Body Communication in Glucose Metabolism.Advances in experimental medicine and biology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Laura L KoekkoekAmsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Tess KoolAmsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Leslie EggelsAmsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Luna L van der GunAmsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Khalid LamuadniAmsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Margo SlompAmsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Charlene DiepenbroekAmsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Mireillle J SerlieAmsterdam University Medical Center, Location AMC, Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Andries KalsbeekAmsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.
Susanne E la FleurAmsterdam University Medical Center, Location AMC, Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam Gastroenterology, Endocrinology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-4298-7451
Netherlands Institute for Neuroscience · NLAmsterdam Neuroscience · NL

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek NWO-VICI grant 016.160.617
6 · The paper itself

Abstract

Opioids are known to affect blood glucose levels but their exact role in the physiological control of glucose metabolism remains unclear. Although there are numerous studies investigating the peripheral effects of opioid stimulation, little is known about how central opioids control blood glucose and which brain areas are involved. One brain area possibly involved is the nucleus accumbens because, as well as being a key site for opioid effects on food intake, it has also been implicated in the control of blood glucose levels. Within the nucleus accumbens, μ-opioid receptors are most abundantly expressed. Therefore, in the present study, we investigated the role of μ-opioid receptors in the nucleus accumbens in the control of glucose metabolism. We show that infusion of the μ-opioid receptor agonist [d-Ala

Indexed as

DAMGOglucose metabolisminsulin tolerance testnucleus accumbensμ-opioid receptor

Identifiers

PMID34528311
PMCPMC9286654
OpenAlexW3198645967

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.