Evidence map›Paper›PMID 34528269›Full record

ArticleThe International journal of eating disorders2021

Lessons learned developing and testing family-based interoceptive exposure for adolescents with low-weight eating disorders.

Tom Hildebrandt, Deena Peyser, Robyn Sysko

Abstract readLetter
In one paragraph

Article in The International journal of eating disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Perceptual Dysfunction in Eating Disorders.Current topics in behavioral neurosciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tom HildebrandtEating and Weight Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-7054-9590
Deena PeyserEating and Weight Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-2012-5364
Robyn SyskoEating and Weight Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-3381-986X

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Reward Systems and Food Avoidance in Adolescents with Low Weight Eating DisordersR01MH109639 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HILDEBRANDT, THOMAS B · 2016 to 2020
$2.9M
NCATS NIH HHS UL1 TR004419NIMH NIH HHS R01 MH109639
6 · The paper itself

Abstract

backgroundAnorexia nervosa (AN) usually develops in early adolescence and is characterized by high rates of morbidity and mortality. Family-based therapy (FBT) is the leading evidence-based treatment for adolescents with AN, but not all patients experience sufficient improvement. The purpose of this manuscript is to describe the development and subsequent experience with a Family-Based Interoceptive Exposure (FBT-IE) for adolescents with a broader form of low-weight eating disorders.

methodsThe novel IE-based behavioral intervention is a six-session family-based treatment module designed to directly target and modify disgust by altering the prefrontal regulation of the insula response to aversive stimuli by decreasing visceral sensitivity (e.g., bloating). Each session teaches a new skill regarding tolerating distress to visceral sensations associated with disgust and an in-vivo "IE exercise," in which the family is provided with a meal replacement shake of unknown content and caloric density.

resultsIn this novel treatment, the patient learns to tolerate disgust in the context of a challenging food stimulus as a way to increase consumption of restricted foods outside of session.

conclusionWe discuss successes and challenges executing this treatment with patients with low-weight eating disorders and propose future directions for the intervention.

Indexed as

Anorexia NervosaDisgustAdolescentFamily TherapyHumansMealsThinnessanorexia nervosaanxietyavoidancedisgust sensitivityinteroceptive exposure

Identifiers

PMID34528269
PMCPMC8712094

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.