Evidence map›Paper›PMID 34528146›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2021

Sympathetic neurovascular transduction following acute hypoxia.

Andrew R Steele, Rachel J Skow, Graham M Fraser, Lindsey F Berthelsen, Craig D Steinback

Abstract read
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In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Hypoxia disrupts neurovascular regulation of blood pressure in normotensive and untreated hypertensive men.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  4. Advancements in the neurocirculatory reflex response to hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Andrew R Steele *Neurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, , University of Alberta, 1-059D Li Ka Shing Centre for Health Research Innovation, Edmonton, AB, Canada, T6G 2E1.
Rachel J Skow *Neurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, , University of Alberta, 1-059D Li Ka Shing Centre for Health Research Innovation, Edmonton, AB, Canada, T6G 2E1.
Graham M FraserDivision of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Lindsey F BerthelsenNeurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, , University of Alberta, 1-059D Li Ka Shing Centre for Health Research Innovation, Edmonton, AB, Canada, T6G 2E1.
Craig D SteinbackNeurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, , University of Alberta, 1-059D Li Ka Shing Centre for Health Research Innovation, Edmonton, AB, Canada, T6G 2E1. craig.steinback@ualberta.ca.
University of Alberta · CAMemorial University of Newfoundland · CA

Funding

canadian network for research and innovation in machining technology, natural sciences and engineering research council of canada RGPIN 05205canadian network for research and innovation in machining technology, natural sciences and engineering research council of canada RGPIN 06637
6 · The paper itself

Abstract

purposeFollowing an acute exposure to hypoxia, sympathetic nerve activity remains elevated. However, this elevated sympathetic nerve activity does not elicit a parallel increase in vascular resistance suggesting a blunted sympathetic signaling [i.e. blunted sympathetic neurovascular transduction (sNVT)]. Therefore, we sought to quantify spontaneous sympathetic bursts and related changes in total peripheral resistance following hypoxic exposure. We hypothesized that following hypoxia sNVT would be blunted.

methodsNine healthy participants (n = 6 men; mean age 25 ± 2 years) were recruited. We collected data on muscle sympathetic nerve activity (MSNA) using microneurography and beat-by-beat total peripheral resistance (TPR) via finger photoplethysmography at baseline, during acute hypoxia and during two periods of recovery (recovery period 1, 0-10 min post hypoxia; recovery period 2, 10-20 min post hypoxia). MSNA burst sequences (i.e. singlets, doublets, triplets and quads+) were identified and coupled to changes in TPR over 15 cardiac cycles as an index of sNVT for burst sequences. A sNVT slope for each participant was calculated from the slope of the relationship between TPR plotted against normalized burst amplitude.

resultsThe sNVT slope was blunted during hypoxia [Δ 0.0044 ± 0.0014 (mmHg/L/min)/(a.u.)], but unchanged following termination of hypoxia [recovery 1, Δ 0.031 ± 0.0019 (mmHg/L/min)/(a.u.); recovery 2, Δ 0.0038 ± 0.0014 (mmHg/L/min)/(a.u.) compared to baseline (Δ 0.038 ± 0.0015 (L/min/mmHg)/(a.u.)] (main effect of group p = 0.012).

conclusionsContrary to our hypothesis, we have demonstrated that systemic sNVT is unchanged following hypoxia in young healthy adults.

Indexed as

HypoxiaSympathetic Nervous SystemAdultBlood PressureHeart RateHemodynamicsHumansMaleMusclesMuscle, SkeletalYoung AdultAcute hypoxiaMuscle sympathetic nerve activitySympathetic neurovascular transductionTotal peripheral resistance

Identifiers

PMID34528146
OpenAlexW3199794054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.