Evidence map›Paper›PMID 34528056›Full record

ArticleAmerican journal of epidemiology2022

Invited Commentary: Drug Checking for Novel Insights Into the Unregulated Drug Supply.

Nabarun Dasgupta, Mary C Figgatt

Abstract readComment
In one paragraph

Article in American journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  17. Xylazine in Drug Seizure Reports and Overdose Deaths in the US, 2018-2022.medRxiv : the preprint server for health sciences · 2023
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Nabarun Dasgupta
Mary C Figgatt

Funding

Infections and Drug Use-Related Morbidity and Mortality among People Who Use DrugsF31DA055345 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FIGGATT, MARY CHARLOT · 2022 to 2023
$60k
NIDA NIH HHS F31 DA055345
6 · The paper itself

Abstract

Tobias et al. (Am J Epidemiol. 2022;191 (2):241-247) present a novel analysis of time trends in fentanyl concentrations in the unregulated drug supply in British Columbia, Canada. The preexisting knowledge about unregulated drugs had come from law-enforcement seizures and postmortem toxicology. As both of these data sources are subject to selection bias, large-scale drug-checking programs are poised to be a crucial component of the public health response to the unrelenting increase in overdose in North America. As programs expand, we offer 2 guiding principles. First, the primary purpose of these programs is to deliver timely results to people who use drugs to mitigate health risks. Second, innovation is needed to go beyond criminal justice paradigms in laboratory analysis for a more nuanced understanding of health concerns. We provide examples of the role adulterants play in our understanding of drug harms. We also describe the applications and limitations of common laboratory assays, with implications for epidemiologic surveillance. While the research and direct service teams in British Columbia have taken groundbreaking steps, there is still a need to establish best practices for communicating results to sample donors in an approachable yet nonalarmist tone.

Indexed as

Drug OverdoseIllicit DrugsBritish ColumbiaFentanylHarm ReductionHumansFentanylIllicit Drugsdrug checkingfentanylharm reductionopioidspublic health surveillancesubstance use

Identifiers

PMID34528056
PMCPMC8824693

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.