ArticleThe Lancet regional health. Western Pacific2021
Tuberculosis in Australia's tropical north: a population-based genomic epidemiological study.
Article in The Lancet regional health. Western Pacific, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Responding to a protracted tuberculosis outbreak: lessons from multiple rounds of investigation in a Chinese boarding school.Annals of medicine · 2026Article
- Use of HIV Phylogenetic Analysis in Public Health in Victoria, Australia: Regulatory Considerations.Journal of bioethical inquiry · 2026Article
- National genomic survey of drug-resistance and multi-jurisdictional clusters ofThe Lancet regional health. Western Pacific · 2026Article
- Temporal trends and spatial variation in nontuberculous mycobacterial notification incidence among First Nations people in Queensland, Australia.BMC infectious diseases · 2026Article
- Epidemiology, Clinical Features, and Outcomes of Chronic Melioidosis in the Top End of Australia's Northern Territory, 1989-2023.Open forum infectious diseases · 2026Article
- Overcoming barriers in tuberculosis control: a case study from a remote community of South Australia.The Lancet regional health. Western Pacific · 2025Article
- Review
- Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic data.Scientific reports · 2025Article
- Parallel signatures of Mycobacterium tuberculosis and human Y-chromosome phylogeography support the Two Layer model of East Asian population history.Communications biology · 2023Article
- Non-tuberculous mycobacterial disease associated withFrontiers in veterinary science · 2023Article
- Article
- Using Genomics to Understand the Epidemiology of Infectious Diseases in the Northern Territory of Australia.Tropical medicine and infectious disease · 2022Review
- Population-based sequencing ofeLife · 2022Article
- Induction therapy and outcome of proliferative lupus nephritis in the top end of Northern Australia - a single centre study retrospective study.BMC nephrology · 2022Article
- Whole-Genome Sequencing and Epidemiological Investigation of Tuberculosis Outbreaks in High Schools in Hunan, China.Infection and drug resistance · 2022Article
- Tuberculosis in Australia's Top End First Nations highlights health and life expectancy gaps: a call to arms.The Lancet regional health. Western Pacific · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Northern Territory (NT) has the highest tuberculosis (TB) rate of all Australian jurisdictions. We combined TB public health surveillance data with genomic sequencing of
methodsThis retrospective observational study included all 741 culture-confirmed cases of TB in the Top End over three decades from 1989-2020. All 497 available
findingsThere were 359 (48%) cases born overseas, 329 (44%) cases among Australian First Nations peoples, and 52 (7%) cases were Australian-born and non-Indigenous. The annual incidence in First Nations peoples from 1989-2019 fell from average 50.4 to 11.0 per 100,000 (P<0·001). First Nations cases were more likely to die from TB (41/329, 12·5%) than overseas-born cases (11/359, 3·1%; P<0·001). Using a threshold of ≤12 SNPs, 28 clusters of between 2-64 individuals were identified, totalling 250 cases; 214 (86%) were First Nations cases and 189 (76%) were from a remote region. The time between cases and past epidemiologically- and genomically-linked contacts ranged from 4·5 months to 24 years.
interpretationOur findings support prioritisation of timely case detection, contact tracing augmented by genomic sequencing, and latent TB treatment to break transmission chains in Top End remote hotspot regions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.