Evidence map›Paper›PMID 34527963›Full record

ArticleHGG advances2021

Joanna J Chmielewska, Deepika Burkardt, Jorge Luis Granadillo, Rachel Slaugh, Shamile Morgan, Joshua Rotenberg, Boris Keren, Cyril Mignot, Luis Escobar, Peter Turnpenny and 6 more

Open access · goldAbstract read
In one paragraph

Article in HGG advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 4 countries.

Joanna J ChmielewskaPostgraduate School of Molecular Medicine, Medical University of Warsaw, Warsaw, Poland.
Deepika BurkardtCenter for Human Genetics and Department of Genetics and Genome Sciences, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH, USA.
Jorge Luis GranadilloDivision of Genetics and Genomic Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Rachel SlaughDivision of Genetics and Genomic Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Shamile MorganHouston Specialty Clinic, Houston, TX, USA.
Joshua RotenbergHouston Specialty Clinic, Houston, TX, USA.
Boris KerenDépartement de Génétique, APHP, Sorbonne Université, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Cyril MignotDépartement de Génétique, APHP, Sorbonne Université, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Luis EscobarMedical Genetics and Neurodevelopmental Center, Peyton Manning Children's Hospital, Indianapolis, IN, USA.
Peter TurnpennyUniversity of Exeter Medical School and Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.
Melissa ZuteckMedical Genetics and Genomics, Spectrum Health/Helen Devos Children's Hospital, Grand Rapids, MI, USA.
Laurie H SeaverMedical Genetics and Genomics, Spectrum Health/Helen Devos Children's Hospital, Grand Rapids, MI, USA.
Rafal PloskiDepartment of Medical Genetics, Warsaw Medical University, Warsaw, Poland.
Magdalena DziembowskaLaboratory of Molecular Basis of Synaptic Plasticity, Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Anthony Wynshaw-BorisCenter for Human Genetics and Department of Genetics and Genome Sciences, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH, USA.
Abidemi AdegbolaCenter for Human Genetics and Department of Genetics and Genome Sciences, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH, USA.
Assistance Publique – Hôpitaux de Paris · FRCenter for Human Genetics · USUniversity of Warsaw · PLWashington University in St. Louis · USCase Western Reserve University · USCorewell Health Blodgett Hospital · USMedical University of Warsaw · PLPeyton Manning Children’s Hospital at St.Vincent · USRoyal Devon & Exeter NHS Foundation Trust · GBSpectrum Health · US

Funding

A conserved transcriptional cascade involved in brain overgrowth, social behavior and autismR01MH113106 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI WYNSHAW-BORIS, ANTHONY J. · 2017 to 2021
$2.9M
NIMH NIH HHS R01 MH113106Wellcome Trust
6 · The paper itself

Abstract

Protein-tyrosine phosphatases (PTPs) are pleomorphic regulators of eukaryotic cellular responses to extracellular signals that function by modulating the phosphotyrosine of specific proteins. A handful of PTPs have been implicated in germline and somatic human disease. Using exome sequencing, we identified missense and truncating variants in

Identifiers

PMID34527963
PMCPMC8439436
OpenAlexW3148939971

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.