Evidence map›Paper›PMID 34527852›Full record

ArticleOTO open

Effect of Radiofrequency Neurolysis on the Symptoms of Chronic Rhinitis: A Randomized Controlled Trial.

J Pablo Stolovitzky, Randall A Ow, Stacey L Silvers, Nadim B Bikhazi, Curtis D Johnson, Masayoshi Takashima

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in OTO open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04533438 nacompletednot on this map

The RhinAer Procedure for Treatment of CHronic RhInitis - A Prospective, MulticeNter Randomized ConTrolled TRial Comparing RhinAer to Sham Control (RHINTRAC)

TypeinterventionalSponsorAerin MedicalRan2020 to 2024Enrolled116ConditionsChronic RhinitisArmsRhinAer Stylus, Sham
NCT07323888 naactive not recruitingnot on this map

Comparison of Traditional Radiofrequency Ablation of Inferior Turbinates With or Without Posterior Nasal Radiofrequency Ablation: A Randomized Controlled Trial

TypeinterventionalSponsorChien Yu HuangRan2026 to 2027Enrolled60ConditionsNasal Obstruction, Chronic Rhinitis, Nonallergic Rhinitis, RhinorrheaArmsTraditional Radiofrequency Ablation of Inferior Turbinates With Posterior Nasal Radiofrequency Ablation, Traditional Radiofrequency Ablation of Inferior Turbinates
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Effectiveness of temperature-controlled radiofrequency neurolysis of the posterior nasal nerve to treat chronic rhinitis: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
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  6. Blue laser turbinate reduction with vs. without posterior nasal neurolysis for refractory rhinitis: a retrospective comparative study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

J Pablo StolovitzkyDepartment of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia, USA.
Randall A OwSacramento Ear Nose and Throat Medical and Surgical Group, Roseville, California, USA.
Stacey L SilversMadison ENT & Facial Plastic Surgery, New York, New York, USA.
Nadim B BikhaziThe Ogden Clinic, Ogden, Utah, USA.
Curtis D JohnsonENT and Allergy Associates of Florida, Plantation, Florida, USA.
Masayoshi TakashimaDepartment of Otolaryngology-Head & Neck Surgery, Houston Methodist Hospital, Houston, Texas, USA.
Arnot Ogden Medical Center · USEar Medical Group · USEmory University · USENT and Allergy Associates of Florida · USMethodist Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the safety and efficacy of temperature-controlled radiofrequency (RF) neurolysis of the posterior nasal nerve (PNN) area for the treatment of chronic rhinitis. STUDY

designA multicenter, prospective, single-blinded, randomized controlled trial, in which the control arm underwent a sham procedure.

settingSixteen otolaryngology centers.

methodsPatients with 24-hour reflective Total Nasal Symptom Score (rTNSS) ≥6, including moderate to severe rhinorrhea and mild to severe congestion, were randomized 2:1 to active treatment of the posterior nasal nerve area with a temperature-controlled RF device or a sham procedure, with no RF energy delivery. The stylus was applied bilaterally to nonoverlapping areas of the posterior middle meatus and posterior inferior turbinate in each nostril in the region of the PNN. The primary endpoint was responder rate at 3 months, where a response was defined as ≥30% improvement (decrease) in rTNSS from baseline.

resultsPatients had a mean baseline rTNSS of 8.3 (95% CI, 7.9-8.7) and 8.2 (95% CI, 7.6-8.8) (

conclusionThis randomized controlled trial showed temperature-controlled neurolysis of the PNN area is free from significant adverse events and superior to a sham procedure in decreasing the symptom burden of chronic rhinitis.

Indexed as

congestionneurolysisposterior nasal nerveradiofrequency ablationrhinitisrhinorrhea

Identifiers

PMID34527852
PMCPMC8436321
OpenAlexW3200513645

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.