Evidence map›Paper›PMID 34527807›Full record

ArticleAdvanced therapeutics2021

Peritumoral Delivery of Docetaxel-TIPS Microparticles for Prostate Cancer Adjuvant Therapy.

Ketevan Paliashvili, Alexander Popov, Tammy L Kalber, P Stephen Patrick, Angela Hayes, Alan Henley, Florence I Raynaud, Hashim U Ahmed, Richard M Day

Open access · hybridAbstract read
In one paragraph

Article in Advanced therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ketevan PaliashviliCentre for Precision Healthcare UCL Division of Medicine University College London Gower Street London WC1E 6BT UK.
Alexander PopovCentre for Precision Healthcare UCL Division of Medicine University College London Gower Street London WC1E 6BT UK.
Tammy L KalberCentre for Advanced Biomedical Imaging UCL Division of Medicine University College London Gower Street London WC1E 6BT UK.
P Stephen PatrickCentre for Advanced Biomedical Imaging UCL Division of Medicine University College London Gower Street London WC1E 6BT UK.
Angela HayesDrug Metabolism Pharmacokinetics and Metabolomics Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research Division of Cancer Therapeutics 15 Cotswold Road Sutton London SM2 5NG UK.
Alan HenleyDrug Metabolism Pharmacokinetics and Metabolomics Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research Division of Cancer Therapeutics 15 Cotswold Road Sutton London SM2 5NG UK.
Florence I RaynaudDrug Metabolism Pharmacokinetics and Metabolomics Cancer Research UK Cancer Therapeutics Unit at The Institute of Cancer Research Division of Cancer Therapeutics 15 Cotswold Road Sutton London SM2 5NG UK.
Hashim U AhmedDivision of Surgery Department of Surgery and Cancer Imperial College London South Kensington Campus London SW7 2AZ UK.
Richard M DayCentre for Precision Healthcare UCL Division of Medicine University College London Gower Street London WC1E 6BT UK.ORCID https://orcid.org/0000-0002-3124-2294
University College London · GBInstitute of Cancer Research · GBImperial College London · GB

Funding

British Heart Foundation FS/15/33/31608Cancer Research UK 22105Cancer Research UK 22897Medical Research Council MR/R026416/1
6 · The paper itself

Abstract

Recurrence of prostate cancer after radical prostatectomy is a consequence of incomplete tumor resection. Systemic chemotherapy after surgery is associated with significant toxicity. Improved delivery methods for toxic drugs capable of targeting positive resection margins can reduce tumor recurrence and avoid their known toxicity. This study evaluates the effectiveness and toxicity of docetaxel (DTX) release from highly porous biodegradable microparticles intended for delivery into the tissue cavity created during radical prostatectomy to target residual tumor cells. The microparticles, composed of poly(dl-lactide-

Indexed as

adjuvant chemotherapydocetaxelmicroparticlespositive resection marginprostate cancerradical prostatectomy

Identifiers

PMID34527807
PMCPMC8427470
OpenAlexW3094264634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.